Anti-AFF4抗体(ab103586)
Key features and details
- Rabbit polyclonal to AFF4
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-AFF4抗体
参阅全部 AFF4 一抗 -
描述
兔多克隆抗体to AFF4 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Recombinant full length protein within Human AFF4 aa 1-400. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
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阳性对照
- Human and Mouse liver tissue lysates; AFF4 transfected 293T cell line lysates
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab103586于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/1000. Predicted molecular weight: 127 kDa.
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说明 |
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WB
1/500 - 1/1000. Predicted molecular weight: 127 kDa. |
靶标
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相关性
May play a role in transcriptional regulation. Component of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor b (P-TEFb). -
细胞定位
Nuclear -
数据库链接
- Entrez Gene: 27125 Human
- Entrez Gene: 93736 Mouse
- Omim: 604417 Human
- SwissProt: Q9UHB7 Human
- SwissProt: Q9ESC8 Mouse
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别名
- AF4/FMR2 family member 4 antibody
- AF5Q31 antibody
- Alf4 antibody
see all
图片
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Anti-AFF4 antibody (ab103586) at 1/500 dilution + Human liver tissue lysate at 50 µg
Predicted band size: 127 kDa -
Anti-AFF4 antibody (ab103586) at 1/500 dilution + Mouse liver tissue lysate at 50 µg
Predicted band size: 127 kDa -
All lanes : Anti-AFF4 antibody (ab103586) at 1/500 dilution
Lane 1 : AFF4 transfected 293T cell line lysate
Lane 2 : Non-transfected 293T cell line lysate
Lysates/proteins at 25 µg per lane.
Predicted band size: 127 kDa
数据表及文件
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Datasheet download
文献 (6)
ab103586 被引用在 6 文献中.
- Li X et al. A proteolysis-targeting chimera molecule selectively degrades ENL and inhibits malignant gene expression and tumor growth. J Hematol Oncol 15:41 (2022). WB ; Mouse . PubMed: 35395864
- Wu F et al. Small-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses malignant gene expression and tumor growth. Theranostics 11:8172-8184 (2021). PubMed: 34373735
- Li J et al. Long noncoding RNA ZFPM2-AS1 is involved in lung adenocarcinoma via miR-511-3p/AFF4 pathway. J Cell Biochem 121:2534-2542 (2020). PubMed: 31692047
- Zheng L et al. Triptonide Modulates MAPK Signaling Pathways and Exerts Anticancer Effects via ER Stress-Mediated Apoptosis Induction in Human Osteosarcoma Cells. Cancer Manag Res 12:5919-5929 (2020). PubMed: 32765093
- Olson CM et al. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat Chem Biol 14:163-170 (2018). PubMed: 29251720
- Zhou CC et al. AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs. Bone Res 5:17044 (2017). WB ; Human . PubMed: 28955517