概述

  • 产品名称Anti-AFAP抗体
    参阅全部 AFAP 一抗
  • 描述
    兔多克隆抗体to AFAP
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within amino acids 301-350 (QVKRKKSSKS EAKGTVSKVT GKKITKIISL GKKKPSTDEQ TSSAEEDVPT) of Human AFAP(NP_940997).

性能

应用

Our Abpromise guarantee covers the use of ab101961 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 81 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.
  • 组织特异性Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer cell lines MCF-7, T-47D and ZR75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and MDA-MB-435. Overexpressed in prostate carcinoma.
  • 序列相似性Contains 2 PH domains.
  • 翻译后修饰Phosphorylated on tyrosine residues by SRC.
  • 细胞定位Cytoplasm > cytoskeleton. Localizes with stress fibers in quiescent cells, concentrated in cell motility structures such as lamellipodia, filopodia and membrane ruffles upon their induction.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 110 kDa actin filament associated protein antibody
    • 110 kDa actin filament-associated protein antibody
    • Actin filament associated protein 1 antibody
    • Actin filament associated protein 110 kDa antibody
    • Actin filament-associated protein 1 antibody
    • AFAP 1 antibody
    • AFAP 110 antibody
    • AFAP antibody
    • AFAP-110 antibody
    • Afap1 antibody
    • AFAP1_HUMAN antibody
    • AFAP110 antibody
    • FLJ56849 antibody
    see all

Anti-AFAP antibody 图像

  • Anti-AFAP antibody (ab101961) at 1 µg + Human liver

    Predicted band size : 81 kDa

Anti-AFAP antibody (ab101961)参考文献

ab101961 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"