Anti-Adiponectin Receptor 2抗体- Aminoterminal end (ab53399)

概述

  • 产品名称
    Anti-Adiponectin Receptor 2抗体- Aminoterminal end
    参阅全部 Adiponectin Receptor 2 一抗
  • 描述
    山羊多克隆抗体to Adiponectin Receptor 2 - Aminoterminal end
  • 经测试应用
    适用于: WB, ICC, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat
  • 免疫原

    Synthetic peptide:

    CSRTPEPDIRLRKGHQLDGTRRGDNDSHQG

    , corresponding to N terminal amino acids 11-40 of Human Adiponectin Receptor 2

  • 阳性对照
    • Human liver; human muscle;

应用

Our Abpromise guarantee covers the use of ab53399 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 44 kDa.
ICC 1/400.
IHC-P Use at an assay dependent dilution.

靶标

  • 功能
    Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.
  • 组织特异性
    Highly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung.
  • 序列相似性
    Belongs to the ADIPOR family.
  • 结构域
    The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular.
  • 细胞定位
    Membrane. Localized to the cell membrane and intracellular organelles.
  • Information by UniProt
  • 数据库链接
  • 别名
    • PAQR2 antibody
    • ACDCR2 antibody
    • Adiponectin receptor protein 2 antibody
    • Adipor2 antibody
    • ADR2_HUMAN antibody
    • Progestin and adipoQ receptor family member II antibody
    see all

图片

  • IH paraffin section human liver with ab53399 at a dilution of 1/250.
  • IH paraffin section human muscle with ab53399 at a dilution of 1/250.

文献

This product has been referenced in:
  • Fang F  et al. Adiponectin attenuates angiotensin II-induced oxidative stress in renal tubular cells through AMPK and cAMP-Epac signal transduction pathways. Am J Physiol Renal Physiol 304:F1366-74 (2013). Read more (PubMed: 23535586) »

See 1 Publication for this product

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