Anti-Adiponectin Receptor 1抗体(ab77611)

概述

  • 产品名称Anti-Adiponectin Receptor 1抗体
    参阅全部 Adiponectin Receptor 1 一抗
  • 描述
    山羊多克隆抗体to Adiponectin Receptor 1
  • 特异性Recognizes Human ADPR1 Receptor. Not likely to cross react with ADPR2.
  • 经测试应用适用于: WB, IHC-P, ICCmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Chicken, Cow, Cat, Pig, Xenopus laevis
  • 免疫原

    Synthetic peptide:

    CYAARIPERFFPGKFDIWFQSHQIF

    , corresponding to C terminal amino acids 317-340 of Human Adiponectin Receptor 1

  • 阳性对照
    • Human liver tissue and human muscle tissue

性能

应用

Our Abpromise guarantee covers the use of ab77611 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
ICC
  • 应用说明ICC: 1/400 (acetone fixed cells).
    IHC-P: 1/250. Recommended buffer: 10 mM KHPO4, 140 mM NaCl, pH 7.2.
    WB: 1/1000. Predicted molecular weight: 42 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.
    • 组织特异性Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine.
    • 序列相似性Belongs to the ADIPOR family.
    • 结构域The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular.
    • 细胞定位Membrane. Localized to the cell membrane and intracellular organelles.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ACDCR1 antibody
      • ADIPO R1 antibody
      • Adiponectin receptor protein 1 antibody
      • ADIPOR 1 antibody
      • Adipor1 antibody
      • ADR1_HUMAN antibody
      • CGI 45 antibody
      • CGI 45 protein antibody
      • CGI-45 antibody
      • CGI45 antibody
      • CGI45 protein antibody
      • FLJ25385 antibody
      • FLJ42464 antibody
      • PAQR1 antibody
      • Progestin and adipoQ receptor family member I antibody
      • TESBP1A antibody
      see all

    Anti-Adiponectin Receptor 1 antibody 图像

    • Paraffin section of human liver tissue stained using antibody to human ADPR1 receptor C-terminus ab77611 at 1/250 dilution.
    • Paraffin section of human muscle tissue stained using antibody to human ADPR1 receptor C-terminus ab77611 at 1/250 dilution.

    Anti-Adiponectin Receptor 1 antibody (ab77611)参考文献

    ab77611 has not yet been referenced specifically in any publications.

    Product Wall

    Abcam guarantees this product to work in the species/application used in this Abreview.
    Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample Human Tissue sections (Liver)
    Specification Liver
    Fixative Paraformaldehyde
    Antigen retrieval step Heat mediated - Buffer/Enzyme Used: Citric acid
    Permeabilization No
    Blocking step Normal goat serum as blocking agent for 15 minute(s) · Concentration: 10% · Temperature: 25°C
    Username

    Abcam user community

    Verified customer

    提交于 Apr 08 2010

    Application Flow Cytometry
    Sample Human Cell (mesothelioma)
    Specification mesothelioma
    Fixation non-fix
    Permeabilization No
    Gating Strategy R2
    Username

    Abcam user community

    Verified customer

    提交于 Jan 27 2010

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"