Anti-Adiponectin Receptor 1抗体(ab77611)

概述

  • 产品名称
    Anti-Adiponectin Receptor 1抗体
    参阅全部 Adiponectin Receptor 1 一抗
  • 描述
    山羊多克隆抗体to Adiponectin Receptor 1
  • 特异性
    Recognizes Human ADPR1 Receptor. Not likely to cross react with ADPR2.
  • 经测试应用
    适用于: WB, IHC-P, ICCmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Chicken, Cow, Cat, Pig, Xenopus laevis
  • 免疫原

    Synthetic peptide:

    CYAARIPERFFPGKFDIWFQSHQIF

    , corresponding to C terminal amino acids 317-340 of Human Adiponectin Receptor 1

  • 阳性对照
    • Human liver tissue and human muscle tissue

性能

应用

Our Abpromise guarantee covers the use of ab77611 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
ICC
  • 应用说明
    ICC: 1/400 (acetone fixed cells).
    IHC-P: 1/250. Recommended buffer: 10 mM KHPO4, 140 mM NaCl, pH 7.2.
    WB: 1/1000. Predicted molecular weight: 42 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.
    • 组织特异性
      Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine.
    • 序列相似性
      Belongs to the ADIPOR family.
    • 结构域
      The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular.
    • 细胞定位
      Membrane. Localized to the cell membrane and intracellular organelles.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ACDCR1 antibody
      • ADIPO R1 antibody
      • Adiponectin receptor protein 1 antibody
      • ADIPOR 1 antibody
      • Adipor1 antibody
      • ADR1_HUMAN antibody
      • CGI 45 antibody
      • CGI 45 protein antibody
      • CGI-45 antibody
      • CGI45 antibody
      • CGI45 protein antibody
      • FLJ25385 antibody
      • FLJ42464 antibody
      • PAQR1 antibody
      • Progestin and adipoQ receptor family member I antibody
      • TESBP1A antibody
      see all

    Anti-Adiponectin Receptor 1 antibody 图像

    • Paraffin section of human liver tissue stained using antibody to human ADPR1 receptor C-terminus ab77611 at 1/250 dilution.
    • Paraffin section of human muscle tissue stained using antibody to human ADPR1 receptor C-terminus ab77611 at 1/250 dilution.

    Anti-Adiponectin Receptor 1 antibody (ab77611)参考文献

    This product has been referenced in:
    • Basu S  et al. Cellular Expression of Cyclooxygenase, Aromatase, Adipokines, Inflammation and Cell Proliferation Markers in Breast Cancer Specimen. PLoS One 10:e0138443 (2015). Read more (PubMed: 26431176) »

    See 1 Publication for this product

    Product Wall

    Abcam guarantees this product to work in the species/application used in this Abreview.
    Application
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample
    Human Tissue sections (Liver)
    Specification
    Liver
    Fixative
    Paraformaldehyde
    Antigen retrieval step
    Heat mediated - Buffer/Enzyme Used: Citric acid
    Permeabilization
    No
    Blocking step
    Normal goat serum as blocking agent for 15 minute(s) · Concentration: 10% · Temperature: 25°C
    Username

    Abcam user community

    Verified customer

    提交于 Apr 08 2010

    Application
    Flow Cytometry
    Sample
    Human Cell (mesothelioma)
    Specification
    mesothelioma
    Fixation
    non-fix
    Permeabilization
    No
    Gating Strategy
    R2
    Username

    Abcam user community

    Verified customer

    提交于 Jan 27 2010

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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