Anti-Adenomatous polyposis coli protein 2抗体(ab106600)

概述

  • 产品名称
    Anti-Adenomatous polyposis coli protein 2抗体
    参阅全部 Adenomatous polyposis coli protein 2 一抗
  • 描述
    兔多克隆抗体to Adenomatous polyposis coli protein 2
  • 特异性
    ab106600 is predicted to not cross-react with other Apc family members. At least four isoforms of Apc2 are known to exist.
  • 经测试应用
    适用于: ICC/IF, WB, ICCmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide corresponding to Human Apc2 (internal sequence).
    Database link: O95996

  • 阳性对照
    • HeLa cells and cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab106600 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 244 kDa.
ICC Use a concentration of 5 µg/ml.

靶标

  • 功能
    Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling.
  • 组织特异性
    Widely expressed (at protein level). Specifically expressed in the CNS.
  • 序列相似性
    Belongs to the adenomatous polyposis coli (APC) family.
    Contains 6 ARM repeats.
  • 发展阶段
    Expressed in fetal brain.
  • 细胞定位
    Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasm. Cytoplasm, perinuclear region. Associated with actin filaments (PubMed:11691822). Associated with microtubule network (PubMed:10644998, PubMed:11691822).
  • Information by UniProt
  • 数据库链接
  • 别名
    • Adenomatous polyposis coli protein 2 antibody
    • Adenomatous polyposis coli protein-like antibody
    • APC-like antibody
    • apc2 antibody
    • APC2_HUMAN antibody
    • APCL antibody
    see all

Anti-Adenomatous polyposis coli protein 2 antibody 图像

  • Immunofluorescence of Apc2 in HeLa cells with ab106600 at 20 ug/mL.

  • Lane 1 : Anti-Adenomatous polyposis coli protein 2 antibody (ab106600) at 1 µg/ml
    Lane 2 : Anti-Adenomatous polyposis coli protein 2 antibody (ab106600) at 2 µg/ml

    Lane 1 : HeLa cell lysate
    Lane 2 : HeLa cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 244 kDa
  • Immunocytochemical analysis of ab106600 at 5 µg/ml in HeLa cells.

Anti-Adenomatous polyposis coli protein 2 antibody (ab106600)参考文献

ab106600 has not yet been referenced specifically in any publications.

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