Anti-ADCY10/SAC抗体(ab203204)
Key features and details
- Rabbit polyclonal to ADCY10/SAC
- Suitable for: IHC-P
- Reacts with: Rat, Human
- Isotype: IgG
概述
-
产品名称
Anti-ADCY10/SAC抗体 -
描述
兔多克隆抗体to ADCY10/SAC -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Rat, Human -
免疫原
Synthetic peptide within Human ADCY10/SAC aa 1100-1200 conjugated to keyhole limpet haemocyanin. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: Q96PN6 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA, 48.98% TBS, 1X -
Concentration information loading...
-
纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab203204于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P |
1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Use at 1/50 - 1/200 with fluorescent detection methods. |
说明 |
---|
IHC-P
1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Use at 1/50 - 1/200 with fluorescent detection methods. |
靶标
-
相关性
ADCY10 belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is localized in the cytoplasm and is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction. -
细胞定位
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note: Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin. -
数据库链接
- Entrez Gene: 55811 Human
- Entrez Gene: 59320 Rat
- Omim: 605205 Human
- SwissProt: Q96PN6 Human
- SwissProt: Q9Z286 Rat
-
别名
- 3',5'-cyclic AMP synthetase antibody
- Adenylate cyclase 10 (soluble) antibody
- Adenylate cyclase 10 antibody
see all
图片
-
Immunohistochemistry on Formalin/PFA-fixed paraffin-embedded rat brain tissue labeling ADCY10/SAC with ab203204 at a 1/200 dilution, followed by conjugation to the secondary antibody Goat anti-rabbit IgG-Cy3 at a 1/200 dilution.
-
Immunohistochemistry on Formalin/PFA-fixed paraffin-embedded rat lung tissue labeling ADCY10/SAC with ab203204 at a 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.
-
Immunohistochemistry on Formalin/PFA-fixed paraffin-embedded human liver cancer tissue labeling ADCY10/SAC with ab203204 at a 1/100 dilution, followed by conjugation to the secondary antibody and DAB staining.
数据表及文件
-
SDS download
-
Datasheet download
文献 (4)
ab203204 被引用在 4 文献中.
- Liu G et al. Long non-coding RNA DPP10-AS1 exerts anti-tumor effects on colon cancer via the upregulation of ADCY1 by regulating microRNA-127-3p. Aging (Albany NY) 13:9748-9765 (2021). PubMed: 33744851
- Zhang X et al. Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma. Theranostics 11:5650-5674 (2021). PubMed: 33897873
- Shaw PX et al. Soluble Adenylyl Cyclase Is Required for Retinal Ganglion Cell and Photoreceptor Differentiation. Invest Ophthalmol Vis Sci 57:5083-5092 (2016). IHC-Fr ; Mouse . PubMed: 27679853
- Nixon B et al. The Australian saltwater crocodile (Crocodylus porosus) provides evidence that the capacitation of spermatozoa may extend beyond the mammalian lineage. Proc Biol Sci 283:N/A (2016). PubMed: 27147099