Anti-ADAMTS4抗体- C-terminal (ab82300)

概述

  • 产品名称
    Anti-ADAMTS4抗体- C-terminal
    参阅全部 ADAMTS4 一抗
  • 描述
    兔多克隆抗体to ADAMTS4 - C-terminal
  • 经测试应用
    适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    KLH conjugated synthetic peptide selected from the C-terminal region of human ADAMTS4.

  • 阳性对照
    • Mouse cerebellum tissue lysate.

性能

应用

Our Abpromise guarantee covers the use of ab82300 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/50 - 1/100. Predicted molecular weight: 90 kDa.
ELISA 1/1000.

靶标

  • 功能
    Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-
    -Ala-393' site.
  • 组织特异性
    Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles.
  • 序列相似性
    Contains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
    Contains 1 TSP type-1 domain.
  • 结构域
    The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻译后修饰
    The precursor is cleaved by a furin endopeptidase.
  • 细胞定位
    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • A disintegrin and metalloproteinase with thrombospondin motifs 4 antibody
    • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 4 antibody
    • A disintegrin like and metalloprotease with thrombospondin type 1 motif 4 antibody
    • ADAM metallopeptidase with thrombospondin type 1 motif 4 antibody
    • ADAM TS 4 antibody
    • ADAM TS4 antibody
    • ADAM-TS 4 antibody
    • ADAM-TS4 antibody
    • ADAMTS 2 antibody
    • ADAMTS 4 antibody
    • ADAMTS-4 antibody
    • ADAMTS2 antibody
    • ADAMTS4 antibody
    • ADAMTS4 protein antibody
    • ADMP 1 antibody
    • ADMP-1 antibody
    • ADMP1 antibody
    • Aggrecanase 1 antibody
    • Aggrecanase-1 antibody
    • Aggrecanase1 antibody
    • ATS4_HUMAN antibody
    • KIAA0688 antibody
    see all

图片

  • Anti-ADAMTS4 antibody - C-terminal (ab82300) at 1/50 dilution + mouse cerebellum tissue lysate at 35 µg

    Predicted band size : 90 kDa
    Observed band size : 90 kDa

实验方案

文献

This product has been referenced in:
  • Keller KE  et al. Differential effects of ADAMTS-1, -4, and -5 in the trabecular meshwork. Invest Ophthalmol Vis Sci 50:5769-77 (2009). Read more (PubMed: 19553617) »

See 1 Publication for this product

客户评价及客户问答

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We guarantee many of the ADAMTS4 antibodies in our catalog to work in Western Blot on human derived samples. While I admit that I am not an expert on this target I assume that because you are looking to test th...

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