Anti-ADAMTS4抗体- C-terminal (ab82300)


  • 产品名称Anti-ADAMTS4抗体- C-terminal
    参阅全部 ADAMTS4 一抗
  • 描述
    兔多克隆抗体to ADAMTS4 - C-terminal
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    KLH conjugated synthetic peptide selected from the C-terminal region of human ADAMTS4.

  • 阳性对照
    • Mouse cerebellum tissue lysate.



Our Abpromise guarantee covers the use of ab82300 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/50 - 1/100. Predicted molecular weight: 90 kDa.
ELISA 1/1000.


  • 功能Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-
    -Ala-393' site.
  • 组织特异性Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles.
  • 序列相似性Contains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
    Contains 1 TSP type-1 domain.
  • 结构域The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻译后修饰The precursor is cleaved by a furin endopeptidase.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • A disintegrin and metalloproteinase with thrombospondin motifs 4 antibody
    • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 4 antibody
    • A disintegrin like and metalloprotease with thrombospondin type 1 motif 4 antibody
    • ADAM metallopeptidase with thrombospondin type 1 motif 4 antibody
    • ADAM TS 4 antibody
    • ADAM TS4 antibody
    • ADAM-TS 4 antibody
    • ADAM-TS4 antibody
    • ADAMTS 2 antibody
    • ADAMTS 4 antibody
    • ADAMTS-4 antibody
    • ADAMTS2 antibody
    • ADAMTS4 antibody
    • ADAMTS4 protein antibody
    • ADMP 1 antibody
    • ADMP-1 antibody
    • ADMP1 antibody
    • Aggrecanase 1 antibody
    • Aggrecanase-1 antibody
    • Aggrecanase1 antibody
    • ATS4_HUMAN antibody
    • KIAA0688 antibody
    see all

Anti-ADAMTS4 antibody - C-terminal 图像

  • Anti-ADAMTS4 antibody - C-terminal (ab82300) at 1/50 dilution + mouse cerebellum tissue lysate at 35 µg

    Predicted band size : 90 kDa
    Observed band size : 90 kDa

Anti-ADAMTS4 antibody - C-terminal (ab82300)参考文献

This product has been referenced in:
  • Keller KE  et al. Differential effects of ADAMTS-1, -4, and -5 in the trabecular meshwork. Invest Ophthalmol Vis Sci 50:5769-77 (2009). Read more (PubMed: 19553617) »

See 1 Publication for this product

Product Wall

Thank you for contacting us.

We guarantee many of the ADAMTS4 antibodies in our catalog to work in Western Blot on human derived samples. While I admit that I am not an expert on this target I assume that because you are looking to test th...

Read More