概述

  • 产品名称Anti-ADAMTS4抗体
    参阅全部 ADAMTS4 一抗
  • 描述
    兔多克隆抗体to ADAMTS4
  • 特异性ab111905 is specific for ADAMTS4 and shows no cross-reactivity with other ADAMTS family members.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Cow, Human, Pig
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide: C-

    VMAHVDPEEP

    (with a Cysteine residue linker), corresponding to amino acids 390-399 of Mouse ADAMTS4 according to Q8BNJ2.

性能

应用

Our Abpromise guarantee covers the use of ab111905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 90 kDa. This antibody detects ADAMTS4 at ~68, ~53 and 30 kDa protein representing ADAMTS4 and its proteolytic fragments. Depending on the extent of C-terminal processing, several smaller bands may also be seen using this antibody.

靶标

  • 功能Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-
    -Ala-393' site.
  • 组织特异性Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles.
  • 序列相似性Contains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
    Contains 1 TSP type-1 domain.
  • 结构域The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻译后修饰The precursor is cleaved by a furin endopeptidase.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • A disintegrin and metalloproteinase with thrombospondin motifs 4 antibody
    • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 4 antibody
    • A disintegrin like and metalloprotease with thrombospondin type 1 motif 4 antibody
    • ADAM metallopeptidase with thrombospondin type 1 motif 4 antibody
    • ADAM TS 4 antibody
    • ADAM TS4 antibody
    • ADAM-TS 4 antibody
    • ADAM-TS4 antibody
    • ADAMTS 2 antibody
    • ADAMTS 4 antibody
    • ADAMTS-4 antibody
    • ADAMTS2 antibody
    • ADAMTS4 antibody
    • ADAMTS4 protein antibody
    • ADMP 1 antibody
    • ADMP-1 antibody
    • ADMP1 antibody
    • Aggrecanase 1 antibody
    • Aggrecanase-1 antibody
    • Aggrecanase1 antibody
    • ATS4_HUMAN antibody
    • KIAA0688 antibody
    see all

Anti-ADAMTS4 antibody (ab111905)参考文献

ab111905 has not yet been referenced specifically in any publications.

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