概述

  • 产品名称Anti-ADAMTS2抗体
    参阅全部 ADAMTS2 一抗
  • 描述
    小鼠单克隆抗体to ADAMTS2
  • 经测试应用适用于: WB, IHC-Frmore details
  • 种属反应性
    与反应: Rat, Human
  • 免疫原

    Recombinant fragment: KHNDIDVFMP TLPVPTVAME VRPSPSTPLE VPLNASSTNA TEDHPETNAV DEPYKIHGLE DEVQPPNLIP RRPSPYEKTR NQRIQELIDE MRKKEMLGK, corresponding to amino acids 1112-1211 of Human ADAMTS2

性能

应用

Our Abpromise guarantee covers the use of ab56735 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 135 kDa.
IHC-Fr Use at an assay dependent concentration. PubMed: 24343133

靶标

  • 功能Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis.
  • 组织特异性Expressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain.
  • 疾病相关Defects in ADAMTS2 are the cause of Ehlers-Danlos syndrome type 7C (EDS7C) [MIM:225410]. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7C is marked by extremely fragile tissues, hyperextensible skin and easy bruising. Facial skin contains numerous folds, as in the cutis laxa syndrome.
  • 序列相似性Contains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
    Contains 1 PLAC domain.
    Contains 4 TSP type-1 domains.
  • 结构域The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • 翻译后修饰The precursor is cleaved by a furin endopeptidase.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • A disintegrin and metalloproteinase with thrombospondin motifs 2 antibody
    • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 2 antibody
    • ADAM metallopeptidase with thrombospondin type 1 motif 2 antibody
    • ADAM TS 2 antibody
    • ADAM TS2 antibody
    • ADAM-TS 2 antibody
    • ADAM-TS2 antibody
    • ADAMTS 3 antibody
    • ADAMTS-2 antibody
    • ADAMTS2 antibody
    • ATS2_HUMAN antibody
    • EC 3.4.24.14 antibody
    • EDS VIIB antibody
    • EDS VIIC antibody
    • hPCPNI antibody
    • NPI antibody
    • PC I NP antibody
    • PC I-NP antibody
    • PCINP antibody
    • PCPNI antibody
    • pNPI antibody
    • Procollagen I N proteinase antibody
    • Procollagen I N-proteinase antibody
    • Procollagen I/II amino propeptide processing enzyme antibody
    • Procollagen I/II amino propeptide-processing enzyme antibody
    • Procollagen N endopeptidase antibody
    • Procollagen N-endopeptidase antibody
    see all

Anti-ADAMTS2 antibody 图像



  • Predicted band size : 135 kDa
    ADAMTS2 antibody (ab56735) at 1ug/lane + PC-12 cell lysate at 25ug/lane.

Anti-ADAMTS2 antibody (ab56735)参考文献

This product has been referenced in:
  • Alarab M  et al. Expression of Extracellular Matrix-Remodeling Proteins Is Altered in Vaginal Tissue of Premenopausal Women With Severe Pelvic Organ Prolapse. Reprod Sci N/A:N/A (2013). WB, IHC-Fr ; Human . Read more (PubMed: 24343133) »

See 1 Publication for this product

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