概述

  • 产品名称Anti-ADAMTS13抗体
    参阅全部 ADAMTS13 一抗
  • 描述
    山羊多克隆抗体to ADAMTS13
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Human
    预测可用于: Gorilla
  • 免疫原

    Synthetic peptide from a region between residue 825 and 875 of human ADAMTS13 (NP_620594.1)

  • 阳性对照
    • Pooled normal human serum.

性能

应用

Our Abpromise guarantee covers the use of ab72335 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IP
  • 应用说明IP: 1-5 µg/µl serum.
    WB: 1/1,000 - 1/10,000. Predicted molecular weight: 154 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Cleaves the vWF multimers in plasma into smaller forms.
    • 组织特异性Plasma. Expressed primarily in liver.
    • 疾病相关Defects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP) [MIM:274150]; also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever.
    • 序列相似性Contains 2 CUB domains.
      Contains 1 disintegrin domain.
      Contains 1 peptidase M12B domain.
      Contains 8 TSP type-1 domains.
    • 结构域The pro-domain is not required for folding or secretion and does not perform the common function of maintening enzyme latency.
      The spacer domain is necessary to recognize and cleave vWF. The C-terminal TSP type-1 and CUB domains may modulate this interaction.
    • 翻译后修饰May contain a C-mannosylation site and O-fucosylation sites in the TSP type-1 domains.
      The precursor is processed by a furin endopeptidase which cleaves off the pro-domain.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • A disintegrin and metalloproteinase with thrombospondin motifs 13 antibody
      • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 13 antibody
      • A disintegrin like and metalloprotease with thrombospondin type 1 motif 13 antibody
      • ADAM metallopeptidase with thrombospondin type 1 motif 13 antibody
      • ADAM TS antibody
      • ADAM-TS 13 antibody
      • ADAM-TS13 antibody
      • ADAMTS 13 antibody
      • ADAMTS-13 antibody
      • ADAMTS13 antibody
      • ADAMTS13 protein antibody
      • ATS13_HUMAN antibody
      • C9orf8 antibody
      • TTP antibody
      • Von Willebrand factor cleaving protease antibody
      • von Willebrand factor-cleaving protease antibody
      • vWF cleaving protease antibody
      • vWF CP antibody
      • vWF-cleaving protease antibody
      • vWF-CP antibody
      • vWFCP antibody
      see all

    Anti-ADAMTS13 antibody 图像

    • Immunoprecipitation/ Western Blot of ADAMTS13.
      Lane 1: ab72335.
      Lane 2: Control IgG.
      ab72335 at 1µg/ml for WB.
      Pooled normal human serum at 300µl/IP, 10% of IP loaded.
      Chemiluminescence with an exposure time of 30 seconds.
      Note: The antibody was conjugated to agarose to produce agarose immobilized antibody. Used at 35µg of antibody per IP.

    Anti-ADAMTS13 antibody (ab72335)参考文献

    ab72335 has not yet been referenced specifically in any publications.

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