Anti-ADAMTS13抗体[20A5] (ab90786)

概述

  • 产品名称
    Anti-ADAMTS13抗体[20A5]
    参阅全部 ADAMTS13 一抗
  • 描述
    小鼠单克隆抗体[20A5] to ADAMTS13
  • 经测试应用
    适用于: ELISA, WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length Human ADAMTS13

  • 表位
    ab90786 recognizes the central to C terminal TSP-1 repeats 2 to 5 of ADAMTS13 (amino acids 686-894).

性能

应用

Our Abpromise guarantee covers the use of ab90786 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.
WB 1/50. Use under non reducing condition. Predicted molecular weight: 154 kDa.
ICC/IF 1/50.

靶标

  • 功能
    Cleaves the vWF multimers in plasma into smaller forms.
  • 组织特异性
    Plasma. Expressed primarily in liver.
  • 疾病相关
    Defects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP) [MIM:274150]; also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever.
  • 序列相似性
    Contains 2 CUB domains.
    Contains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
    Contains 8 TSP type-1 domains.
  • 结构域
    The pro-domain is not required for folding or secretion and does not perform the common function of maintening enzyme latency.
    The spacer domain is necessary to recognize and cleave vWF. The C-terminal TSP type-1 and CUB domains may modulate this interaction.
  • 翻译后修饰
    May contain a C-mannosylation site and O-fucosylation sites in the TSP type-1 domains.
    The precursor is processed by a furin endopeptidase which cleaves off the pro-domain.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • A disintegrin and metalloproteinase with thrombospondin motifs 13 antibody
    • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 13 antibody
    • A disintegrin like and metalloprotease with thrombospondin type 1 motif 13 antibody
    • ADAM metallopeptidase with thrombospondin type 1 motif 13 antibody
    • ADAM TS antibody
    • ADAM-TS 13 antibody
    • ADAM-TS13 antibody
    • ADAMTS 13 antibody
    • ADAMTS-13 antibody
    • ADAMTS13 antibody
    • ADAMTS13 protein antibody
    • ATS13_HUMAN antibody
    • C9orf8 antibody
    • TTP antibody
    • Von Willebrand factor cleaving protease antibody
    • von Willebrand factor-cleaving protease antibody
    • vWF cleaving protease antibody
    • vWF CP antibody
    • vWF-cleaving protease antibody
    • vWF-CP antibody
    • vWFCP antibody
    see all

Anti-ADAMTS13 antibody [20A5] (ab90786)参考文献

ab90786 has not yet been referenced specifically in any publications.

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