概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列CQSRRCRKNAFQEL
    • 氨基酸637 to 650

相关产品

技术指标

Our Abpromise guarantee covers the use of ab45734 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-ADAM33 antibody (ab36172)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • A disintegrin and metalloprotease 33
    • A disintegrin and metalloproteinase domain 33
    • ADA33_HUMAN
    • ADAM 33
    • ADAM metallopeptidase domain 33
    • ADAM33
    • C20orf153
    • Disintegrin and metalloproteinase domain-containing protein 33
    • Disintegrin and reprolysin metalloproteinase family protein
    • DJ964F7.1
    • DKFZp434K0521
    • FLJ35308
    • FLJ36751
    • Metalloprotease disintegrin
    • MGC149823
    • MGC71889
    • PRO1891
    • UNQ873
    see all
  • 组织特异性Expressed in all tissues, except liver, with high expression in placenta, lung, spleen and veins.
  • 疾病相关Genetic variations in ADAM33 are associated with susceptibility to asthma (ASTHMA) [MIM:600807]. The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi.
  • 序列相似性Contains 1 disintegrin domain.
    Contains 1 EGF-like domain.
    Contains 1 peptidase M12B domain.
  • 结构域The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻译后修饰The precursor is cleaved by a furin endopeptidase.
  • 细胞定位Membrane.
  • Information by UniProt

ADAM33 peptide (637-650) (ab45734)参考文献

ab45734 has not yet been referenced specifically in any publications.

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