Hurst LA et al.TNFa drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling.Nat Commun 8:14079 (2017).
Shirakabe K et al.Mechanistic insights into ectodomain shedding: susceptibility of CADM1 adhesion molecule is determined by alternative splicing and O-glycosylation.Sci Rep 7:46174 (2017).
Carnuta MG et al.Dysfunctional high-density lipoproteins have distinct composition, diminished anti-inflammatory potential and discriminate acute coronary syndrome from stable coronary artery disease patients.Sci Rep 7:7295 (2017).
Bolino A et al.Niacin-mediated Tace activation ameliorates CMT neuropathies with focal hypermyelination.EMBO Mol Med 8:1438-1454 (2016).
Chapnick DA et al.A biosensor for the activity of the "sheddase" TACE (ADAM17) reveals novel and cell type-specific mechanisms of TACE activation.Sci Signal 8:rs1 (2015).
Dombernowsky SL et al.The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17.Nat Commun 6:7518 (2015).
Morancho B et al.Role of ADAM17 in the non-cell autonomous effects of oncogene-induced senescence.Breast Cancer Res 17:106 (2015).
Huang Y et al.Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation.Int J Biol Sci 10:702-14 (2014).
Fleck D et al.Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling.J Neurosci 33:7856-69 (2013).
Rothhaar TL et al.Plasmalogens Inhibit APP Processing by Directly Affecting ?-Secretase Activity in Alzheimer's Disease.ScientificWorldJournal 2012:141240 (2012).
Marballi K et al.Differential neuregulin 1 cleavage in the prefrontal cortex and hippocampus in schizophrenia and bipolar disorder: preliminary findings.PLoS One 7:e36431 (2012).
Grimm MO et al.Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms.J Biol Chem 286:14028-39 (2011).