• 产品名称Anti-ADAM15抗体
    参阅全部 ADAM15 一抗
  • 描述
    兔多克隆抗体to ADAM15
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide from near the C terminal residues of human ADAM15.

  • 阳性对照
    • Fetal liver lysate. Human stomach tissue.




Our Abpromise guarantee covers the use of ab84834 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明Peptide ELISA titer: 1/80000.
    IHC-P: 1/100 - 1/500.
    WB: 1/200 - 1/1000. Predicted molecular weight: 88 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.
    • 组织特异性Expressed in colon and small intestine. Expressed in airway smooth muscle and glomerular mesangial cells (at protein level). Ubiquitously expressed. Overexpressed in atherosclerotic lesions. Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes. Expressed in airway smooth muscle and glomerular mesangial cells.
    • 序列相似性Contains 1 disintegrin domain.
      Contains 1 EGF-like domain.
      Contains 1 peptidase M12B domain.
    • 结构域The cytoplasmic domain interacts with endophilin I and sorting nexin 9.
      Disintegrin domain binds to integrin alphaV-beta3.
      The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    • 翻译后修饰The precursor is cleaved by a furin endopeptidase.
      Phosphorylation increases association with PTKs.
    • 细胞定位Endomembrane system. Cell junction > adherens junction. Cell projection > cilium > flagellum. Cytoplasmic vesicle > secretory vesicle > acrosome. The majority of the protein is localized in a perinuclear compartment which may correspond to the trans-Golgi network or the late endosome. The pro-protein is the major detectable form on the cell surface, whereas the majority of the protein in the cell is processed.
    • Information by UniProt
    • 数据库链接
    • 别名
      • A disintegrin and metalloproteinase domain 15 (metargidin) antibody
      • A disintegrin and metalloproteinase domain 15 antibody
      • ADA15_HUMAN antibody
      • ADAM 15 antibody
      • ADAM metallopeptidase domain 15 antibody
      • Adam15 antibody
      • and cysteine-rich protein 15 antibody
      • Disintegrin and metalloproteinase domain-containing protein 15 antibody
      • disintegrin-like antibody
      • EC 3.4.24. antibody
      • MDC 15 antibody
      • MDC-15 antibody
      • MDC15 antibody
      • Metalloprotease RGD disintegrin protein antibody
      • Metalloproteinase like disintegrin like and cysteine rich protein 15 antibody
      • Metalloproteinase-like antibody
      • Metargidin antibody
      see all

    Anti-ADAM15 antibody 图像

    • Anti-ADAM15 antibody (ab84834) at 1/200 dilution + fetal liver lysate

      Predicted band size : 88 kDa
      Observed band size : 55 kDa (why is the actual band size different from the predicted?)
    • ab84834, at 1/100 dilution, staining ADAM15 in formalin-fixed paraffin-embedded Human stomach tissue by Immunohistochemistry.

    Anti-ADAM15 antibody (ab84834)参考文献

    ab84834 has not yet been referenced specifically in any publications.

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