概述

  • 产品名称Anti-ADAM12抗体
    参阅全部 ADAM12 一抗
  • 描述
    山羊多克隆抗体to ADAM12
  • 种属反应性

    预测可用于: Mouse, Rat, Dog, Chinese Hamster
  • 免疫原

    Peptide with sequence C-

    KKTTMEKLRCVHP

    , corresponding to internal sequence amino acids 740-752 of Mouse ADAM12 (NP_031426.2)

  • 阳性对照
    • Mouse and Rat Skeletal Muscle lysates

性能

应用

  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors.
    • 组织特异性Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas.
    • 序列相似性Contains 1 disintegrin domain.
      Contains 1 EGF-like domain.
      Contains 1 peptidase M12B domain.
    • 结构域The cysteine-rich domain supports cell adhesion through syndecans and triggers signaling events that lead to beta-1 integrin-dependent cell spreading. In carcinomas cells the binding of this domain to syndecans does not allow the integrin-mediated cell spreading.
      The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    • 翻译后修饰The precursor is cleaved by a furin endopeptidase.
    • 细胞定位Secreted and Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • A disintegrin and metalloproteinase domain 12 antibody
      • ADA12_HUMAN antibody
      • ADAM 12 antibody
      • ADAM metallopeptidase domain 12 antibody
      • ADAM12 antibody
      • Disintegrin and metalloproteinase domain-containing protein 12 antibody
      • MCMP antibody
      • MCMPMltna antibody
      • Meltrin alpha antibody
      • Meltrin-alpha antibody
      • MLTN antibody
      • MLTNA antibody
      • OTTHUMP00000046766 antibody
      see all

    Anti-ADAM12 antibody (ab123504)参考文献

    ab123504 has not yet been referenced specifically in any publications.

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