RabMAb

Anti-ADA抗体[EPR4438] (ab108352)

概述

  • 产品名称Anti-ADA抗体[EPR4438]
    参阅全部 ADA 一抗
  • 描述
    兔单克隆抗体[EPR4438] to ADA
  • 经测试应用适用于: WB, IP, ICCmore details
    不适用于: Flow Cyt or IHC-P
  • 种属反应性
    与反应: Rat, Human
  • 免疫原

    A synthetic peptide corresponding to residues in Human ADA

  • 阳性对照
    • Jurkat, fetal thymus, and rat kidney lysates
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

应用

Our Abpromise guarantee covers the use of ab108352 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 41 kDa.
IP 1/10 - 1/100.
ICC 1/250 - 1/500.
  • 应用说明Is unsuitable for Flow Cyt or IHC-P.
  • 靶标

    • 功能Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.
    • 组织特异性Found in all tissues, occurs in large amounts in T-lymphocytes and, at the time of weaning, in gastrointestinal tissues.
    • 疾病相关Defects in ADA are the cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-negative due to adenosine deaminase deficiency (ADASCID) [MIM:102700]. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients with SCID present in infancy with recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. ADA-SCID is an autosomal recessive form accounting for about 50% of non-X-linked SCIDs. ADA deficiency has been diagnosed in chronically ill teenagers and adults (late or adult onset). Population and newborn screening programs have also identified several healthy individuals with normal immunity who have partial ADA deficiency.
    • 序列相似性Belongs to the adenosine and AMP deaminases family.
    • 细胞定位Cell membrane. Cell junction. Cytoplasmic vesicle lumen. Cytoplasm. Colocalized with DPP4 at the cell junction in lymphocyte-epithelial cell adhesion.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ada antibody
      • ADA_HUMAN antibody
      • ADA1 antibody
      • Adenosine aminohydrolase antibody
      • Adenosine deaminase antibody
      see all

    Anti-ADA antibody [EPR4438] 图像

    • All lanes : Anti-ADA antibody [EPR4438] (ab108352) at 1/1000 dilution

      Lane 1 : Jurkat cell lysate
      Lane 2 : Human fetal thymus lysate
      Lane 3 : Rat kidney tissue lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 41 kDa
      Observed band size : 41 kDa

    Anti-ADA antibody [EPR4438] (ab108352)参考文献

    ab108352 has not yet been referenced specifically in any publications.

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