概述

  • 产品名称Anti-ACVRL1抗体
    参阅全部 ACVRL1 一抗
  • 描述
    兔多克隆抗体to ACVRL1
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to Human ACVRL1 (C terminal).
    Database link: NM_020661

  • 阳性对照
    • Human hepatocellular carcinoma tissue and Human fetal heart lysate

性能

应用

Our Abpromise guarantee covers the use of ab93595 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
  • 应用说明IHC-P: 1/100 - 1/300.
    WB: 1/200 - 1/5000. Predicted molecular weight: 56 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
    • 疾病相关Defects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia.
    • 序列相似性Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
      Contains 1 GS domain.
      Contains 1 protein kinase domain.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Activin A receptor antibody
      • Activin A receptor type II like 1 antibody
      • Activin A receptor, type II like kinase 1 antibody
      • Activin receptor like kinase 1 antibody
      • Activin receptor-like kinase 1 antibody
      • ACVL1_HUMAN antibody
      • ACVRL1 antibody
      • ACVRLK1 antibody
      • ALK-1 antibody
      • ALK1 antibody
      • HHT antibody
      • HHT2 antibody
      • ORW2 antibody
      • Osler Rendu Weber syndrome 2 antibody
      • Serine/threonine protein kinase receptor R3 antibody
      • Serine/threonine-protein kinase receptor R3 antibody
      • SKR3 antibody
      • TGF B superfamily receptor type I antibody
      • TGF-B superfamily receptor type I antibody
      • TSR-I antibody
      • TSR1 antibody
      see all

    Anti-ACVRL1 antibody 图像

    • Anti-ACVRL1 antibody (ab93595) at 1/200 dilution + Human fetal heart lysate

      Predicted band size : 56 kDa
    • Immunohistochemical staining of formalin-fixed paraffin-embedded hepatocellular liver carcinoma using ab93595 at 1/100 dilution.

    Anti-ACVRL1 antibody (ab93595)参考文献

    ab93595 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab93595.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"