Anti-Activin Receptor Type IIB抗体(ab99070)


  • 产品名称Anti-Activin Receptor Type IIB抗体
    参阅全部 Activin Receptor Type IIB 一抗
  • 描述
    兔多克隆抗体to Activin Receptor Type IIB
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Sheep, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Drosophila melanogaster, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal amino acids 287-336 (LCHVAETMSR GLSYLHEDVP WCRGEGHKPS IAHRDFKSKN VLLKSDLTAV) of Human Activin Receptor Type IIB (NP_001097).

  • 阳性对照
    • PANC1 cell lysate



Our Abpromise guarantee covers the use of ab99070 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 58 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • 功能On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
  • 疾病相关Defects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4) [MIM:613751]. A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defects. Clinical features of visceral heterotaxy type 4 include dextrocardia, right aortic arch and a right-sided spleen, anomalies of the inferior and the superior vena cava, atrial ventricular canal defect with dextro-transposed great arteries, pulmonary stenosis, polysplenia and midline liver.
  • 序列相似性Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 protein kinase domain.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Activin A receptor type IIB antibody
    • Activin receptor type 2B antibody
    • Activin receptor type IIB antibody
    • Activin receptor type-2B antibody
    • ActR IIB antibody
    • ACTR-IIB antibody
    • ActRIIB antibody
    • ACVR 2B antibody
    • ACVR2B antibody
    • AVR2B_HUMAN antibody
    • HTX4 antibody
    • MGC116908 antibody
    see all

Anti-Activin Receptor Type IIB antibody 图像

  • Anti-Activin Receptor Type IIB antibody (ab99070) at 1 µg/ml + PANC1 cell lysate at 10 µg

    Predicted band size : 58 kDa

Anti-Activin Receptor Type IIB antibody (ab99070)参考文献

ab99070 has not yet been referenced specifically in any publications.

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Human Cell lysate - whole cell (ovarian cancer cell lines)
Loading amount 45 µg
Specification ovarian cancer cell lines
Gel Running Conditions Reduced Denaturing (4-12% NuPAGE gel with MOPS running buffer)
Blocking step Licor/Oddessey Blocking buffer as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 100% · Temperature: 22°C

Dr. Jennifer Markovics

Verified customer

提交于 Dec 15 2010