Anti-Activin Receptor Type IA抗体(ab115301)

概述

  • 产品名称Anti-Activin Receptor Type IA抗体
    参阅全部 Activin Receptor Type IA 一抗
  • 描述
    山羊多克隆抗体to Activin Receptor Type IA
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Goat, Horse, Cow, Dog, Pig
  • 免疫原

    Synthetic peptide:

    C-RKFKRRNQERLNPRD

    , corresponding to internal sequence amino acids 147-161 of Human Activin Receptor Type IA.

  • 阳性对照
    • Human Testis tissue; Human Umbilical Cord lysate

性能

应用

Our Abpromise guarantee covers the use of ab115301 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 57 kDa.
ELISA 1/128000.
IHC-P Use a concentration of 4 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis.
  • 组织特异性Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells.
  • 疾病相关Defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:135100]. FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.
  • 序列相似性Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Activin A receptor type I antibody
    • Activin A receptor type II like kinase 2 antibody
    • Activin receptor type I antibody
    • Activin receptor type-1 antibody
    • Activin receptor-like kinase 2 antibody
    • ACTR-I antibody
    • ACTRI antibody
    • Acvr1 antibody
    • ACVR1_HUMAN antibody
    • ACVR1A antibody
    • ACVRLK2 antibody
    • ALK 2 antibody
    • ALK-2 antibody
    • ALK2 antibody
    • FOP antibody
    • Hydroxyalkyl protein kinase antibody
    • Serine/threonine-protein kinase receptor R1 antibody
    • SKR1 antibody
    • TGF-B superfamily receptor type I antibody
    • TGFB superfamily receptor type I antibody
    • TSR-I antibody
    • TSRI antibody
    see all

Anti-Activin Receptor Type IA antibody 图像

  • ab115301, at 4 µg/ml, staining Activin Receptor Type IA in formalin-fixed, paraffin-embedded Human Testis by Immunohistochemistry, using a biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Anti-Activin Receptor Type IA antibody (ab115301) at 0.3 µg/ml + Human Umbilical Cord lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 57 kDa

Anti-Activin Receptor Type IA antibody (ab115301)参考文献

ab115301 has not yet been referenced specifically in any publications.

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Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products. I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused...

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Thank you for your email. The antibody dilutions vary from antibody to antibody. For ab47086, the recommended dilution range is 3 - 5 µg/ml. For ab115301, the recommended dilution range is 0.3 - 1 µg/ml. But the optimal dilutions/concentrations should ...

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Thank you for contacting us. The WB protocol for ab115301 is as follows: Western blot protocol - The membrane is blocked in 3% (w/v) skimmed milk in TBS -T for 1 hr at room temperature with agitation (can be blocked overnight at 4°C without ...

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