Anti-Activin A Receptor Type IB抗体(ab77049)

概述

  • 产品名称Anti-Activin A Receptor Type IB抗体
    参阅全部 Activin A Receptor Type IB 一抗
  • 描述
    兔多克隆抗体to Activin A Receptor Type IB
  • 特异性At least three isoforms of ACVR1B are known to exist. This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1C.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide corresponding to Human Activin A Receptor Type IB (C terminal). ACVR1B antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of the human ACVR1B.
    Database link: P36896

  • 阳性对照
    • Human kidney tissue lysate
  • 常规说明

    Antibodies should not be exposed to prolonged high temperatures.

性能

应用

Our Abpromise guarantee covers the use of ab77049 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 57 kDa.

靶标

  • 功能On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TDP2.
  • 组织特异性Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.
  • 序列相似性Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • 翻译后修饰Autophosphorylated.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 形式There are 3 isoforms produced by alternative splicing. Isoform 1 also known as SKR2-1; isoform 2 as SKR2-2; isoform 3 as SKR2-3.
  • 别名
    • Activin A receptor type 1B antibody
    • Activin A receptor type II like kinase 4 antibody
    • Activin A type 1B receptor antibody
    • Activin A type IB receptor antibody
    • Activin receptor like kinase 4 antibody
    • Activin receptor type 1B antibody
    • Activin receptor type IB antibody
    • Activin receptor type-1B antibody
    • Activin receptor-like kinase 4 antibody
    • ACTR IB antibody
    • ACTR-IB antibody
    • ACTRIB antibody
    • ACV1B_HUMAN antibody
    • ACVR 1B antibody
    • Acvr1b antibody
    • ACVRLK 4 antibody
    • ACVRLK4 antibody
    • ALK 4 antibody
    • ALK-4 antibody
    • ALK4 antibody
    • Serine(threonine) protein kinase receptor R2 antibody
    • Serine/threonine-protein kinase receptor R2 antibody
    • SKR 2 antibody
    • SKR2 antibody
    see all

Anti-Activin A Receptor Type IB antibody 图像

  • All lanes : Anti-Activin A Receptor Type IB antibody (ab77049) at 1 µg/ml

    Lane 1 : human kidney tissue lysate
    Lane 2 : human kidney tissue lysate with blocking peptide

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 57 kDa
    Observed band size : 66 kDa (why is the actual band size different from the predicted?)

Anti-Activin A Receptor Type IB antibody (ab77049)参考文献

This product has been referenced in:
  • Colas AR  et al. Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis. Genes Dev 26:2567-79 (2012). Read more (PubMed: 23152446) »

See 1 Publication for this product

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