Active人TRIM5 gamma肽(ab41839)

概述

  • 产品名称
    Active人TRIM5 gamma肽

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human

相关产品

技术指标

Our Abpromise guarantee covers the use of ab41839 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    Blocking the activity of the TRIM5 gamma antibody (ab17203).
  • 应用

    Blocking - Blocking peptide for Anti-TRIM5 gamma antibody (ab17203)

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • RING finger protein 88
    • RNF88
    • TRIM5
    • TRIM5_HUMAN
    • Tripartite motif containing 5
    • Tripartite motif protein TRIM5
    • Tripartite motif-containing protein 5
    see all
  • 功能
    Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity.
  • 通路
    Protein modification; protein ubiquitination.
  • 序列相似性
    Belongs to the TRIM/RBCC family.
    Contains 1 B box-type zinc finger.
    Contains 1 B30.2/SPRY domain.
    Contains 1 RING-type zinc finger.
  • 结构域
    The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
  • 翻译后修饰
    Ubiquitinates itself in a RING finger- and UBE2D2-dependent manner (in vitro).
  • 细胞定位
    Cytoplasm > P-body. Cytoplasmic bodies.
  • Information by UniProt

Active human TRIM5 gamma peptide (ab41839)参考文献

ab41839 has not yet been referenced specifically in any publications.

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