概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human

相关产品

技术指标

Our Abpromise guarantee covers the use of ab40018 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    TLR5 peptide is used for blocking the activity of TLR5 antibody ab37071.
  • 应用

    Blocking

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • FLJ10052
    • MGC126430
    • MGC126431
    • SLEB1
    • TIL 3
    • TIL3
    • TLR 5
    • Tlr5
    • TLR5_HUMAN
    • Toll like receptor 5
    • Toll like receptor 5 precursor
    • Toll-like receptor 5
    • Toll/interleukin 1 receptor like protein 3
    • Toll/interleukin-1 receptor-like protein 3
    see all
  • 功能
    Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
  • 组织特异性
    Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.
  • 疾病相关
    Systemic lupus erythematosus 1
  • 序列相似性
    Belongs to the Toll-like receptor family.
    Contains 22 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 TIR domain.
  • 翻译后修饰
    Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines.
    Phosphorylated at Tyr-798 upon flagellin binding; required for signaling.
  • 细胞定位
    Membrane.
  • Information by UniProt

Active human TLR5 peptide (ab40018)参考文献

ab40018 has not yet been referenced specifically in any publications.

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