Active人Parathyroid Hormone肽(ab68899)

概述

描述

  • 性质
    Synthetic
  • 来源
    Escherichia coli
  • 氨基酸序列
    • 种属
      Human
    • 序列
      LMH NLGKHLNSME RVEWLRKKLQ DVHNF
    • 分子量
      3 kDa
    • 氨基酸
      7 to 34

技术指标

Our Abpromise guarantee covers the use of ab68899 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    The activity calculated by UMR106 cell/cAMP method corresponds to a specific activity of 1.0 x 104 Units/mg.
  • 应用

    SDS-PAGE

  • 纯度
    > 95 % SDS-PAGE.
    Purity is greater than 97.0% as determined by analysis by RP-HPLC and SDS-PAGE, purified by proprietary chromatographic techniques.
  • 形式
    Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 4% Mannitol, 20mM PBS, pH 7

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 复溶
    Reconstitute in sterile 18MOhm/cm water to not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).

常规信息

  • 别名
    • hPTH
    • Parathormone
    • Parathyrin
    • Parathyroid hormone
    • Parathyroid hormone 1
    • Prepro PTH
    • Preproparathyroid hormone
    • PTH
    • PTH1
    • PTH1 receptor
    • PTH1R
    • PTHR
    • PTHR1
    • PTHY_HUMAN
    see all
  • 功能
    PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
  • 疾病相关
    Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
  • 序列相似性
    Belongs to the parathyroid hormone family.
  • 细胞定位
    Secreted.
  • Information by UniProt

文献

ab68899 has not yet been referenced specifically in any publications.

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