概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human

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技术指标

Our Abpromise guarantee covers the use of ab39927 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性blocking the activity of ATF6 antibody (ab37149).
  • 应用

    Blocking - Blocking peptide for Anti-ATF6 antibody (ab37149)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • Activating transcription factor 6
    • Activating transcription factor 6 alpha
    • ATF 6
    • ATF6
    • ATF6 alpha
    • ATF6-alpha
    • ATF6A
    • ATF6A_HUMAN
    • cAMP dependent transcription factor ATF 6 alpha
    • cAMP-dependent transcription factor ATF-6 alpha
    • Cyclic AMP dependent transcription factor ATF 6 alpha
    • DKFZp686P2194
    • ESTM49
    • FLJ21663
    • Processed cyclic AMP dependent transcription factor ATF 6 alpha
    • Processed cyclic AMP-dependent transcription factor ATF-6 alpha
    see all
  • 功能Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor.
  • 组织特异性Ubiquitous.
  • 序列相似性Belongs to the bZIP family. ATF subfamily.
    Contains 1 bZIP domain.
  • 结构域The basic domain functions as a nuclear localization signal.
    The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE.
  • 翻译后修饰During unfolded protein response an approximative 50 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases.
    N-glycosylated. The glycosylation status may serve as a sensor for ER homeostasis, resulting in ATF6 activation to trigger the unfolded protein response (UPR).
    Phosphorylated in vitro by MAPK14/P38MAPK.
  • 细胞定位Endoplasmic reticulum membrane and Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
  • Information by UniProt

Active human ATF6 peptide (ab39927)参考文献

ab39927 has not yet been referenced specifically in any publications.

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