Anti-active Caspase 6抗体(ab2326)

概述

  • 产品名称Anti-active Caspase 6抗体
  • 描述
    兔多克隆抗体to active Caspase 6
  • 特异性This antibody recognizes the large subunit (18 kDa) of the active caspase 6. The antibody does not recognize any other caspase.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to Human active Caspase 6. Synthetic peptide surrounding amino acids mapping to the C-terminus of the large fragment of Human Caspase-6.

  • 常规说明


    The caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase 6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase 3, caspase 6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase 6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 30% Glycerol, 0.5% BSA, PBS, pH 7.2
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • Primary antibody说明The caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase 6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase 3, caspase 6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase 6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab2326 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml.

靶标

Anti-active Caspase 6 antibody (ab2326)参考文献

This product has been referenced in:
  • Li X  et al. Concomitant inactivation of foxo3a and fancc or fancd2 reveals a two-tier protection from oxidative stress-induced hydrocephalus. Antioxid Redox Signal 21:1675-92 (2014). Mouse . Read more (PubMed: 24483844) »

See 1 Publication for this product

Product Wall

Thanks for your enquiry.

I am sorry but we do not have a western blot available for this antibody.

When you refer to Abcam's "policy regarding antibodies", I presume you mean a guarantee. We do have a guarantee which we re...

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This antibody reacts specifically to the large sub-unit (18 kDa) of the active caspase-6.

I hope this is helpful. Please contact me again if you have any further questions.

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunocytochemistry/ Immunofluorescence
Sample Human Cell (HeLa)
Specification HeLa
Fixative Paraformaldehyde
Permeabilization Yes - 0.5% Triton X100 in PBS
Username

Dr. Kirk McManus

Verified customer

提交于 Oct 14 2008

We have three caspase 6 antibodies, none have been tested in IHC.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"