概述

  • 产品名称Anti-Acinus抗体
    参阅全部 Acinus 一抗
  • 描述
    兔多克隆抗体to Acinus
  • 特异性The antibody recognises three different splice forms of Acinus, designated Acinus L, Acinus S and Acinus S'.
  • 经测试应用适用于: ICC/IF, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    DTSENRPENDVPEPP

    , corresponding to amino acids 775-789 of Human Acinus L, 48 to 62 of human Acinus S’, or 17 to 31 of human Acinus S, which differ from those of mouse Acinus by one amino acid.

  • 阳性对照
    • K562 whole cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab7354 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF
WB
  • 应用说明ICC/IF: Use at a concentration of 5 µg/ml.
    WB: Use at a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 220 kDa (predicted molecular weight: 151 kDa). Can be blocked with Acinus (internal) peptide (human)


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3.
    • 组织特异性Ubiquitous.
    • 序列相似性Contains 1 SAP domain.
    • 翻译后修饰Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ACIN 1 antibody
      • ACIN1 antibody
      • ACINU_HUMAN antibody
      • Acinus antibody
      • ACN antibody
      • Apoptotic chromatin condensation inducer 1 antibody
      • Apoptotic chromatin condensation inducer in the nucleus antibody
      • DKFZp667N107 antibody
      • fSAP152 antibody
      • functional spliceosome-associated protein 152 antibody
      • KIAA0670 antibody
      see all

    Anti-Acinus antibody 图像

    • Immunofluorescence of Acinus in K562 cells with ab7354 at 20 ug/mL.

    • Anti-Acinus antibody (ab7354) at 1 µg/ml + K562 whole cell lysate

      Predicted band size : 151 kDa
    • ab7354 at 5µg/ml staining Acinus in K562 cells by ICC/IF

    Anti-Acinus antibody (ab7354)参考文献

    ab7354 has not yet been referenced specifically in any publications.

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