概述

  • 产品名称Anti-Acinus抗体
    参阅全部 Acinus 一抗
  • 描述
    兔多克隆抗体to Acinus
  • 特异性Recognizes Acinus L, Acinus S and Acinus S'.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    6HIS fusion protein, corresponding to amino acids 1233-1341 of Human Acinus.

  • 阳性对照
    • Jurkat lysate

性能

应用

Our Abpromise guarantee covers the use of ab18519 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 0.5 - 1 µg/ml. Detects Acinus L, Acinus S and Acinus S' at 220, 98 and 94 kDa respectively, in RIPA lysates from Jurkat cells. Detection of Acinus L was lost in Jurkat cells treated with 0.5 µM staurosporin for 6 hours. Loss of Acinus L is observed upon induction of apoptosis.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3.
    • 组织特异性Ubiquitous.
    • 序列相似性Contains 1 SAP domain.
    • 翻译后修饰Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ACIN 1 antibody
      • ACIN1 antibody
      • ACINU_HUMAN antibody
      • Acinus antibody
      • ACN antibody
      • Apoptotic chromatin condensation inducer 1 antibody
      • Apoptotic chromatin condensation inducer in the nucleus antibody
      • DKFZp667N107 antibody
      • fSAP152 antibody
      • functional spliceosome-associated protein 152 antibody
      • KIAA0670 antibody
      see all

    Anti-Acinus antibody (ab18519)参考文献

    ab18519 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"