Anti-Acid Phosphatase 2抗体(ab85719)

概述

  • 产品名称Anti-Acid Phosphatase 2抗体
    参阅全部 Acid Phosphatase 2 一抗
  • 描述
    山羊多克隆抗体to Acid Phosphatase 2
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Dog, Cynomolgus Monkey, Orangutan
  • 免疫原

    Synthetic peptide:

    C-QNETRQTPEYQN

    , corresponding to internal sequence amino acids 166-177 of Human Acid Phosphatase 2

  • 阳性对照
    • Human prostate tissue.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab85719 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/16000.
IHC-P Use a concentration of 5 µg/ml.

靶标

  • 疾病相关Defects in ACP2 are a cause of acid phosphatase deficiency (ACPHD) [MIM:200950]. The clinical features are intermittent vomiting, hypotonia, lethargy, opisthotonos, terminal bleeding, and death in early infancy. Lysosomal acid phosphatase is deficient in cultured fibroblasts and multiple tissues.
  • 序列相似性Belongs to the histidine acid phosphatase family.
  • 翻译后修饰The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen.
    N-glycosylated. The intermediates formed during enzymatic deglycosylation suggest that all eight predicted N-glycosylation sites are used.
  • 细胞定位Lysosome membrane. Lysosome lumen. The soluble form arises by proteolytic processing of the membrane-bound form.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Acid phosphatase 2 lysosomal antibody
    • ACP 2 antibody
    • ACP2 antibody
    • LAP antibody
    • Lysosomal acid phosphatase 2 antibody
    • Lysosomal acid phosphatase antibody
    • PPAL_HUMAN antibody
    see all

Anti-Acid Phosphatase 2 antibody 图像

  • ab85719, at 5µg/ml, staining Acid Phosphatase 2 in formalin-fixed, paraffin-embedded Human prostate tissue by Immunohistochemistry.

Anti-Acid Phosphatase 2 antibody (ab85719)参考文献

ab85719 has not yet been referenced specifically in any publications.

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