概述

  • 产品名称Anti-ABI2抗体
    参阅全部 ABI2 一抗
  • 描述
    小鼠多克隆抗体to ABI2
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    ABI2 (NP_005750.4, 475 a.a), full-length human protein.

  • 阳性对照
    • ABI2 transfected 293T cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 1X PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab70144 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 60 kDa (predicted molecular weight: 52 kDa).
ICC/IF Use a concentration of 10 µg/ml.

靶标

  • 功能May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.
  • 序列相似性Belongs to the ABI family.
    Contains 1 SH3 domain.
    Contains 1 t-SNARE coiled-coil homology domain.
  • 翻译后修饰Is a substrate for ABL1.
  • 细胞定位Cytoplasm and Cell projection > lamellipodium. Cell projection > filopodium. Cytoplasm > cytoskeleton. Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Abelson interactor 2 antibody
    • ABI 2 antibody
    • Abi-2 antibody
    • ABI2 antibody
    • ABI2_HUMAN antibody
    • ABI2B antibody
    • Abl binding protein 3 antibody
    • Abl interacting protein 1 (SH3 containing protein) antibody
    • Abl interactor 2 antibody
    • Abl interactor protein 2b antibody
    • Abl-binding protein 3 antibody
    • AblBP3 antibody
    • AIP 1 antibody
    • Arg binding protein 1 antibody
    • Arg protein tyrosine kinase binding protein antibody
    • Arg-binding protein 1 antibody
    • ArgBP1 antibody
    • ARGBPIA antibody
    • ArgBPIB antibody
    • OTTHUMP00000163783 antibody
    • OTTHUMP00000163784 antibody
    • OTTHUMP00000206182 antibody
    • OTTHUMP00000206183 antibody
    • OTTHUMP00000206184 antibody
    • OTTHUMP00000206185 antibody
    • SSH3BP2 antibody
    see all

Anti-ABI2 antibody 图像

  • All lanes : Anti-ABI2 antibody (ab70144) at 1/500 dilution

    Lane 1 : transfected 293T cell lysate
    Lane 2 : non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 52 kDa
    Observed band size : 60 kDa (why is the actual band size different from the predicted?)
  • ab70144 at 10µg/ml staining ABl2 in Hela cells by Immunocytochemistry/Immunofluorescence.

Anti-ABI2 antibody (ab70144)参考文献

This product has been referenced in:
  • Maddala R  et al. Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. Dev Biol : (2011). WB ; Mouse . Read more (PubMed: 21945075) »

See 1 Publication for this product

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