概述

  • 产品名称
  • 描述
    小鼠多克隆抗体to ABHD12
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length Human protein (NP_056415.1, aa 1 to ~404)

  • 阳性对照
    • ABHD12-transfected 293T cell lysate

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: None
    Constituents: 1X PBS, pH 7.2
  • Concentration information loading...
  • 纯度
    Protein A purified
  • 克隆
    多克隆
  • 同种型
    IgG

应用

Our Abpromise guarantee covers the use of ab68949 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 45 kDa (predicted molecular weight: 45 kDa).

靶标

  • 功能
    Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways.
  • 疾病相关
    Defects in ABHD12 are the cause of polyneuropathy hearing loss ataxia retinitis pigmentosa and cataract (PHARC) [MIM:612674]. PHARC is a slowly progressive neurologic disorder with a variable phenotype resembling Refsum disease. Clinical features include sensorineural hearing loss, visual problems related to cataracts, retinitis pigmentosa, pes cavus, ataxic and/or spastic gait disturbances with a progressive sensorimotor peripheral neuropathy. Other features include hyporeflexia, hyperreflexia, extensor plantar responses.
  • 序列相似性
    Belongs to the serine esterase family.
  • 翻译后修饰
    Glycosylated.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2-arachidonoylglycerol hydrolase antibody
    • 6330583M11Rik antibody
    • ABD12_HUMAN antibody
    • ABHD12 antibody
    • ABHD12A antibody
    • Abhydrolase domain containing protein 12 antibody
    • Abhydrolase domain-containing protein 12 antibody
    • AI431047 antibody
    • AW547313 antibody
    • BEM46L2 antibody
    • C20orf22 antibody
    • Monoacylglycerol lipase ABHD12 antibody
    • RP23-241M12.2 antibody
    see all

图片

  • All lanes : Anti-ABHD12 antibody (ab68949) at 1/500 dilution

    Lane 1 : ABHD12 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP conjugated at 1/2500 dilution

    Predicted band size : 45 kDa
    Observed band size : 45 kDa

实验方案

文献

This product has been referenced in:
  • Navia-Paldanius D  et al. Biochemical and pharmacological characterization of human a/ß-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12). J Lipid Res 53:2413-24 (2012). WB . Read more (PubMed: 22969151) »

See 1 Publication for this product

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