RabMAb

Anti-ABCG5抗体[EPR6203] (ab124965)

概述

  • 产品名称Anti-ABCG5抗体[EPR6203]
    参阅全部 ABCG5 一抗
  • 描述
    兔单克隆抗体[EPR6203] to ABCG5
  • 经测试应用适用于: WBmore details
    不适用于: Flow Cyt,ICC/IF,IHC-P or IP
  • 种属反应性
    与反应: Human
    不与反应: Mouse, Rat
  • 免疫原

    Synthetic peptide, corresponding to residues in Human ABCG5.

  • 阳性对照
    • Ramos and HepG2 cell lysates.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

性能

应用

Our Abpromise guarantee covers the use of ab124965 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 75 kDa (predicted molecular weight: 72 kDa).
  • 应用说明Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
  • 靶标

    • 功能Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.
    • 组织特异性Strongly expressed in the liver, lower levels in the small intestine and colon.
    • 疾病相关Defects in ABCG5 are a cause of sitosterolemia (STSL) [MIM:210250]; also known as phytosterolemia or shellfish sterolemia. It is a rare autosomal recessive disorder characterized by increased intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and decreased biliary excretion of dietary sterols into bile. Sitosterolemia patients have hypercholesterolemia, very high levels of plant sterols in the plasma, and frequently develop tendon and tuberous xanthomas, accelerated atherosclerosis and premature coronary artery disease.
    • 序列相似性Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
      Contains 1 ABC transmembrane type-2 domain.
      Contains 1 ABC transporter domain.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Abcg5 antibody
      • ABCG5_HUMAN antibody
      • ATP binding cassette sub family G (WHITE) member 5 (sterolin 1) antibody
      • ATP binding cassette sub family G member 5 antibody
      • ATP-binding cassette sub-family G member 5 antibody
      • ATP-binding cassette, sub-family G (WHITE), member 5 antibody
      • Sterolin 1 antibody
      • Sterolin-1 antibody
      • STSL antibody
      see all

    Anti-ABCG5 antibody [EPR6203] 图像

    • All lanes : Anti-ABCG5 antibody [EPR6203] (ab124965) at 1/1000 dilution

      Lane 1 : Ramos cell lysates
      Lane 2 : HepG2 cell lysates

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 72 kDa
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    Anti-ABCG5 antibody [EPR6203] (ab124965)参考文献

    ab124965 has not yet been referenced specifically in any publications.

    Product Wall

    I now have more information to share with you in regards to the immunogen used to raise the anti-ABCG5 antibody ab124965. As can be seen from the attachment, the immunogen used to raise this antibody also does not share high homology with the rat prote...

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    Thank you for contacting us and your interest in our products.
    The ABCG5 antibodies which we have are all directed against the human protein. This shares 79% homology with the rat protein. We have not tested any of the anti-ABCG5 antibodies we hav...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"