概述

  • 产品名称Anti-ABCD1抗体
    参阅全部 ABCD1 一抗
  • 描述
    山羊多克隆抗体to ABCD1
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Horse, Dog
  • 免疫原

    Synthetic peptide:

    EDMQRKGYSEQD

    , corresponding to amino acids 564-575 of Human ABCD1 (NP_000024.2)

  • 阳性对照
    • Human brain (cerebellum) lysates

性能

应用

Our Abpromise guarantee covers the use of ab77364 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明Peptide ELISA: Use at an assay dependent dilution. Antibody detection limit dilution: 1/32000.
    WB: Use at a concentration of 1 µg/ml. Predicted molecular weight: 83 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity.
    • 疾病相关Defects in ABCD1 are the cause of adrenoleukodystrophy X-linked (X-ALD) [MIM:300100]. X-ALD is a peroxisomal metabolic disorder characterized by progressive multifocal demyelination of the central nervous system and by peripheral adrenal insufficiency (Addison disease). It results in mental deterioration, corticospinal tract dysfunction, and cortical blindness. Different clinical manifestations exist like: cerebral childhood ALD (CALD), adult cerebral ALD (ACALD), adrenomyeloneuropathy (AMN) and 'Addison disease only' (ADO) phenotype.
      Note=The promoter region of ABCD1 is deleted in the chromosome Xq28 deletion syndrome which involves ABCD1 and the neighboring gene BCAP31.
    • 序列相似性Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
      Contains 1 ABC transmembrane type-1 domain.
      Contains 1 ABC transporter domain.
    • 细胞定位Peroxisome membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ABC42 antibody
      • Abcd1 antibody
      • ABCD1_HUMAN antibody
      • Adrenoleukodystrophy protein antibody
      • ALD antibody
      • Aldgh antibody
      • ALDP antibody
      • AMN antibody
      • ATP binding cassette, sub family D (ALD), member 1 antibody
      • ATP-binding cassette sub-family D member 1 antibody
      • OTTHUMP00000025960 antibody
      • OTTMUSP00000019283 antibody
      • RGD1562128 antibody
      • RP23 373N8.2 antibody
      • X linked adrenoleukodystrophy (ALD) gene homolog antibody
      see all

    Anti-ABCD1 antibody 图像

    • All lanes : Anti-ABCD1 antibody (ab77364) at 1 µg/ml

      Lane 1 : Cell lysate prepared from HEK293 mock transfected cells.
      Lane 2 : Cell lysate prepared from HEK293 cells overexpressing human ABCD1.


      Predicted band size : 83 kDa

    Anti-ABCD1 antibody (ab77364)参考文献

    ab77364 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"