概述

  • 产品名称Anti-ABCD1抗体
    参阅全部 ABCD1 一抗
  • 描述
    兔多克隆抗体to ABCD1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 264-293 of Human ABCD1 (NP_000024.2)

  • 阳性对照
    • HL-60 cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab107094 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 83 kDa.

靶标

  • 功能Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity.
  • 疾病相关Defects in ABCD1 are the cause of adrenoleukodystrophy X-linked (X-ALD) [MIM:300100]. X-ALD is a peroxisomal metabolic disorder characterized by progressive multifocal demyelination of the central nervous system and by peripheral adrenal insufficiency (Addison disease). It results in mental deterioration, corticospinal tract dysfunction, and cortical blindness. Different clinical manifestations exist like: cerebral childhood ALD (CALD), adult cerebral ALD (ACALD), adrenomyeloneuropathy (AMN) and 'Addison disease only' (ADO) phenotype.
    Note=The promoter region of ABCD1 is deleted in the chromosome Xq28 deletion syndrome which involves ABCD1 and the neighboring gene BCAP31.
  • 序列相似性Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
    Contains 1 ABC transmembrane type-1 domain.
    Contains 1 ABC transporter domain.
  • 细胞定位Peroxisome membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ABC42 antibody
    • Abcd1 antibody
    • ABCD1_HUMAN antibody
    • Adrenoleukodystrophy protein antibody
    • ALD antibody
    • Aldgh antibody
    • ALDP antibody
    • AMN antibody
    • ATP binding cassette, sub family D (ALD), member 1 antibody
    • ATP-binding cassette sub-family D member 1 antibody
    • OTTHUMP00000025960 antibody
    • OTTMUSP00000019283 antibody
    • RGD1562128 antibody
    • RP23 373N8.2 antibody
    • X linked adrenoleukodystrophy (ALD) gene homolog antibody
    see all

Anti-ABCD1 antibody 图像

  • Anti-ABCD1 antibody (ab107094) at 1/100 dilution + HL-60 cell lysate at 35 µg

    Predicted band size : 83 kDa

Anti-ABCD1 antibody (ab107094)参考文献

ab107094 has not yet been referenced specifically in any publications.

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