概述

  • 产品名称Anti-ABCC9抗体
    参阅全部 ABCC9 一抗
  • 描述
    兔多克隆抗体to ABCC9
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Goat, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig, Caenorhabditis elegans, Drosophila melanogaster, Zebrafish
  • 免疫原

    Synthetic peptide designed within residues: AVVTEGGENF SVGQRQLFCL ARAFVRKSSI LIMDEATASI DMATENILQK, corresponding to internal sequence amino acids 1440 - 1489 of Human ABCC9 (NP_005682)

  • 阳性对照
    • 721_B cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab84299 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 174 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
  • 疾病相关Defects in ABCC9 are the cause of cardiomyopathy dilated type 1O (CMD1O) [MIM:608569]; also known as dilated cardiomyopathy with ventricular tachycardia. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in ABCC9 are the cause of familial atrial fibrillation type 12 (ATFB12) [MIM:614050]. ATFB12 is a familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.
  • 序列相似性Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ABC37 antibody
    • abcC9 antibody
    • ABCC9_HUMAN antibody
    • AI414027 antibody
    • AI449286 antibody
    • ATFB12 antibody
    • ATP-binding cassette sub-family C member 9 antibody
    • ATP-binding cassette transporter sub-family C member 9 antibody
    • ATP-binding cassette, sub-family C (CFTR/MRP), member 9 antibody
    • CANTU antibody
    • CMD1O antibody
    • FLJ36852 antibody
    • Sulfonylurea receptor 2 antibody
    • Sulfonylurea-binding protein 2 antibody
    • SUR2 antibody
    • SUR2A antibody
    • SUR2B antibody
    see all

Anti-ABCC9 antibody 图像



  • Predicted band size : 174 kDa
    Western blot analysis of 10µg SUR1 KO (lane 1) 10µg WT (lane 2) 0.1µg SUR1 overexpressing (lane 3) mouse ventricle lysates and 10µg cannine ventricle lysate (lane 4) labeling ABCC9 with ab84299 at 1:1000. A HRP-conjugated anti-rabbit (1:2000) was used as the secondary antibody.
  • Anti-ABCC9 antibody (ab84299) at 1 µg/ml + 721_B cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 174 kDa
    Observed band size : 174 kDa
    Additional bands at : 45 kDa,70 kDa. We are unsure as to the identity of these extra bands.

Anti-ABCC9 antibody (ab84299)参考文献

ab84299 has not yet been referenced specifically in any publications.

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