Anti-ABCB11抗体- Carboxyterminal end (ab71793)


  • 产品名称Anti-ABCB11抗体- Carboxyterminal end
    参阅全部 ABCB11 一抗
  • 描述
    兔多克隆抗体to ABCB11 - Carboxyterminal end
  • 特异性We have received some negative reports from customers using this antibody in IHC, therefore we do not recommend this antibody for IHC.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    A KLH conjugated synthetic peptide selected from the C-terminal region of human ABCB11.

  • 阳性对照
    • Human hepatocarcinoma tissue and mouse liver tissue lysate.



Our Abpromise guarantee covers the use of ab71793 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Detects a band of approximately 146 kDa (predicted molecular weight: 146 kDa).
ELISA 1/1000.


  • 功能Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
  • 组织特异性Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.
  • 疾病相关Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis type 2 (PFIC2) [MIM:601847]. PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.
    Defects in ABCB11 are the cause of benign recurrent intrahepatic cholestasis type 2 (BRIC2) [MIM:605479]. BRIC is characterized by intermittent episodes of cholestasis without progression to liver failure. There is initial elevation of serum bile acids, followed by cholestatic jaundice which generally spontaneously resolves after periods of weeks to months. The cholestatic attacks vary in severity and duration and patients are asymptomatic between episodes, both clinically and biochemically.
  • 序列相似性Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
  • 结构域Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ABC member 16, MDR/TAP subfamily antibody
    • ABCB1 antibody
    • Abcb11 antibody
    • ABCBB_HUMAN antibody
    • ATP binding cassette sub family B (MDR/TAP) member 11 antibody
    • ATP binding cassette sub family B member 11 antibody
    • ATP-binding cassette sub-family B member 11 antibody
    • Bile salt export pump antibody
    • BRIC2 antibody
    • Bsep antibody
    • PGY4 antibody
    • progressive familial intrahepatic cholestasis 2 antibody
    • Sister of P glycoprotein antibody
    • Spgp antibody
    see all

Anti-ABCB11 antibody - Carboxyterminal end 图像

  • Anti-ABCB11 antibody - Carboxyterminal end (ab71793) at 1/100 dilution + mouse liver tissue lysate at 12.5 µg

    Predicted band size : 146 kDa
    Observed band size : 146 kDa

Anti-ABCB11 antibody - Carboxyterminal end (ab71793)参考文献

ab71793 has not yet been referenced specifically in any publications.

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Thank you for contacting us. I am sorry to hear you are experiencing difficulties with one of our products and that you do not observe a staining in IHC. We take product complaints very seriously, and investigate every product that we feel may not be p...

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Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Human Cell lysate - whole cell (Human hepatoma cells Huh7)
Loading amount 25 µg
Specification Human hepatoma cells Huh7
Treatment 0.5uM GW4064
Gel Running Conditions Reduced Denaturing (4-12% gradient gel)
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 22°C

Abcam user community

Verified customer

提交于 Oct 05 2011

Thank you for your enquiry. I have contacted the originator of the product for more information, unfortunately the exact immunogen sequence information is proprietary. However, they did released information that the sequence is a 15 amino acid prot...

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