Anti-LYVE1抗体(ab36993)
Key features and details
- Rabbit polyclonal to LYVE1
- Suitable for: WB, IHC-P, IHC-Fr, Flow Cyt
- Reacts with: Dog, Human, Recombinant fragment
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-LYVE1抗体
参阅全部 LYVE1 一抗 -
描述
兔多克隆抗体to LYVE1 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-P, IHC-Fr, Flow Cytmore details -
种属反应性
与反应: Dog, Human, Recombinant fragment -
免疫原
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Lyophilized:Please reconstitue in sterile water to a concentration of 0.1-10mg/ml. When reconstituted the antibody is stable for at least two weeks at 2-8°C. -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
存储溶液
Constituent: PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab36993于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 35 kDa.
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IHC-P | (1) |
Use a concentration of 6 - 30 µg/ml.
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IHC-Fr | (1) |
Use a concentration of 6 - 30 µg/ml.
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Flow Cyt |
Use a concentration of 3 - 10 µg/ml.
ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
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说明 |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 35 kDa. |
IHC-P
Use a concentration of 6 - 30 µg/ml. |
IHC-Fr
Use a concentration of 6 - 30 µg/ml. |
Flow Cyt
Use a concentration of 3 - 10 µg/ml. ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
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靶标
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功能
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. -
组织特异性
Mainly expressed in endothelial cells lining lymphatic vessels. -
序列相似性
Contains 1 Link domain. -
翻译后修饰
O-glycosylated. -
细胞定位
Membrane. Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface. - Information by UniProt
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数据库链接
- Entrez Gene: 10894 Human
- Omim: 605702 Human
- SwissProt: Q9Y5Y7 Human
- Unigene: 655332 Human
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别名
- Cell surface retention sequence-binding protein 1 antibody
- CRSBP 1 antibody
- CRSBP-1 antibody
see all
图片
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IHC with paraffin-embedded sections of human intestine (border area of a colon carcinoma) using antibody ab36993.
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The staining was performed on frozen sections from human colon carcinoma using ab36993 (polyclonal anti-human LYVE-1 antibody; protein-A purified; 10 µg/ml).
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of lymphatic vessels of malignant canine mammary tumor tissue sections labelling LYVE1 with ab36993.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of lymphatic vessels of benign canine mammary tumor tissue sections labelling LYVE1 with ab36993.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of lymphatic vessels of normal canine mammary tissue sections labelling LYVE1 with ab36993.
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Flow Cytometry analysis of human dermal microvascular endothelial cells (HDMVEC) labelling LYVE1 with ab36993.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (14)
ab36993 被引用在 14 文献中.
- Gage BK et al. Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors. Cell Rep 39:110621 (2022). PubMed: 35385743
- Aparicio-Domingo P et al. Fibroblast-derived IL-33 is dispensable for lymph node homeostasis but critical for CD8 T-cell responses to acute and chronic viral infection. Eur J Immunol 51:76-90 (2021). PubMed: 32700362
- Chutipongpisit K et al. Immunohistochemical and immunofluorescence expression profile of lymphatic endothelial cell markers in oral cancer. Int J Exp Pathol 102:268-278 (2021). PubMed: 34791715
- Gage BK et al. Generation of Functional Liver Sinusoidal Endothelial Cells from Human Pluripotent Stem-Cell-Derived Venous Angioblasts. Cell Stem Cell 27:254-269.e9 (2020). IHC-P, Flow Cyt ; Human . PubMed: 32640183
- Ha SK et al. Magnetic Resonance Imaging and Histopathological Visualization of Human Dural Lymphatic Vessels. Bio Protoc 8:N/A (2018). PubMed: 29780855