HRP Anti-Cardiac Troponin I抗体[16A11] (ab24460)
Key features and details
- HRP Mouse monoclonal [16A11] to Cardiac Troponin I
- Suitable for: WB, ELISA, Sandwich ELISA
- Reacts with: Rat, Rabbit, Goat, Cow, Cat, Dog, Human, Pig
- Conjugation: HRP
- Isotype: IgG1
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
HRP Anti-Cardiac Troponin I抗体[16A11]
参阅全部 Cardiac Troponin I 一抗 -
描述
HRP小鼠单克隆抗体[16A11] to Cardiac Troponin I -
宿主
Mouse -
偶联物
HRP -
特异性
Reacts with free cardiac troponin I (cTnI) and cTnI forming complexes with other troponin components (in the presence of 5 mM EDTA). Not affected by heparin, phosphorylation, oxidation and troponin complex formation. Does not cross-react with skeletal muscle troponin I. -
经测试应用
适用于: WB, ELISA, Sandwich ELISAmore details -
种属反应性
与反应: Rat, Rabbit, Goat, Cow, Cat, Dog, Human, Pig
不与反应: Fish -
免疫原
Full length native protein (purified) corresponding to Human Cardiac Troponin I.
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表位
87-91aa -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.40
Preservative: 0.05% Proclin 300
Constituents: 0.8% Sodium chloride, 0.02% Potassium chloride, 0.18% Dibasic monohydrogen sodium phosphate, 0.024% Monobasic dihydrogen potassium phosphate -
Concentration information loading...
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纯度
Protein A purified -
克隆
单克隆 -
克隆编号
16A11 -
骨髓瘤
Sp2/0 -
同种型
IgG1 -
研究领域
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应用
The Abpromise guarantee
Abpromise™承诺保证使用ab24460于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
Use at an assay dependent concentration.
|
|
ELISA |
Use at an assay dependent concentration.
|
|
Sandwich ELISA |
Use at an assay dependent concentration.
|
|
AP |
Use at an assay dependent concentration.
|
说明 |
---|
WB
Use at an assay dependent concentration. |
ELISA
Use at an assay dependent concentration. |
Sandwich ELISA
Use at an assay dependent concentration. |
AP
Use at an assay dependent concentration. |
靶标
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功能
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. -
疾病相关
Defects in TNNI3 are the cause of cardiomyopathy familial hypertrophic type 7 (CMH7) [MIM:613690]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Defects in TNNI3 are the cause of cardiomyopathy familial restrictive type 1 (RCM1) [MIM:115210]. RCM1 is an heart muscle disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.
Defects in TNNI3 are the cause of cardiomyopathy dilated type 2A (CMD2A) [MIM:611880]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Defects in TNNI3 are the cause of cardiomyopathy dilated type 1FF (CMD1FF) [MIM:613286]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. -
序列相似性
Belongs to the troponin I family. - Information by UniProt
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数据库链接
- Entrez Gene: 493744 Cat
- Entrez Gene: 511094 Cow
- Entrez Gene: 403566 Dog
- Entrez Gene: 7137 Human
- Entrez Gene: 100049696 Pig
- Entrez Gene: 29248 Rat
- Omim: 191044 Human
- SwissProt: Q863B6 Cat
see all -
别名
- cardiac muscle antibody
- Cardiac troponin I antibody
- cardiomyopathy, dilated 2A (autosomal recessive) antibody
see all
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab24460 被引用在 1 文献中.
- Banz Y et al. Attenuation of myocardial reperfusion injury in pigs by Mirococept, a membrane-targeted complement inhibitor derived from human CR1. Cardiovasc Res 76:482-93 (2007). PubMed: 17825275