IRS1多肽(ab204862)
Key features and details
- Purity: > 95% HPLC
- Suitable for: Functional Studies, HPLC
描述
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产品名称
IRS1多肽
参阅全部 IRS1 蛋白酶 -
纯度
> 95 % HPLC. -
无动物成分
No -
性质
Synthetic -
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序列
KKKSPGEYVNIEFG -
氨基酸
891 to 902
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相关产品
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Recombinant Protein
技术指标
Our Abpromise guarantee covers the use of ab204862 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
Functional Studies
HPLC
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形式
Lyophilized -
补充说明
ab204862 (IRS1 peptide) can be utilized as a substrate for the following active protein kinases:
ab187246 (Active human ALK protein fragment)
ab84771 (Active human VEGF Receptor 1 full length protein)
ab71657 (Active IGF1 Receptor protein fragment)
ab84791 (Active human Ret protein fragment)
ab125624 (Active human ROS protein fragment) -
Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.
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复溶Dilute peptide in 20mM Tris-HCl, pH 7.5 solution to a final concentration of 1 mg/ml. For optimal storage, aliquot diluted product into smaller quantities and store at recommended temperature.
常规信息
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别名
- HIRS 1
- HIRS1
- Insulin receptor substrate 1
see all -
功能
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. -
疾病相关
Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853]. -
序列相似性
Contains 1 IRS-type PTB domain.
Contains 1 PH domain. -
翻译后修饰
Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
Phosphorylation of Tyr-896 is required for GRB2-binding. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (0)
ab204862 尚未被引用在任何文献中。