重组Anti-HSD3B1抗体[EPR9687] (ab167417)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR9687] to HSD3B1
- Suitable for: WB, ICC/IF
- Reacts with: Human
Related conjugates and formulations
概述
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产品名称
Anti-HSD3B1抗体[EPR9687]
参阅全部 HSD3B1 一抗 -
描述
兔单克隆抗体[EPR9687] to HSD3B1 -
宿主
Rabbit -
特异性
The immunogen used for this product shares 83% homology and 6 continuous identical amino acids with HSD3B2(SwissProt: P26439). Cross-reactivity with this protein has not been confirmed experimentally.
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经测试应用
适用于: WB, ICC/IFmore details
不适用于: IHC-P or IP -
种属反应性
与反应: Human -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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阳性对照
- Human placenta cell lysate, Caco-2 cells.
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading...
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纯度
Tissue culture supernatant -
克隆
单克隆 -
克隆编号
EPR9687 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab167417于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
1/1000 - 1/10000. Predicted molecular weight: 42 kDa.
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ICC/IF |
1/250 - 1/500.
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说明 |
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WB
1/1000 - 1/10000. Predicted molecular weight: 42 kDa. |
ICC/IF
1/250 - 1/500. |
靶标
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功能
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone. -
组织特异性
Placenta and skin. Predominantly expressed in mammary gland tissue. -
通路
Lipid metabolism; steroid biosynthesis. -
序列相似性
Belongs to the 3-beta-HSD family. -
细胞定位
Endoplasmic reticulum membrane. Mitochondrion membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 3283 Human
- Entrez Gene: 3284 Human
- Omim: 109715 Human
- SwissProt: P14060 Human
- SwissProt: P26439 Human
- Unigene: 364941 Human
- Unigene: 654399 Human
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别名
- 3 beta and steroid delta isomerase 1 antibody
- 3 beta and steroid hydroxy delta 5 steroid dehydrogenase antibody
- 3 beta HSD I antibody
see all
图片
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab167417 被引用在 4 文献中.
- Fraichard C et al. Protease Inhibitor Anti-HIV, Lopinavir, Impairs Placental Endocrine Function. Int J Mol Sci 22:N/A (2021). PubMed: 33445576
- E Silva PV et al. Effects of isolated or combined exposure to sibutramine and rosuvastatin on reproductive parameters of adult male rats. J Appl Toxicol 40:947-964 (2020). PubMed: 32072669
- Nedder M et al. Uptake of Cerium Dioxide Nanoparticles and Impact on Viability, Differentiation and Functions of Primary Trophoblast Cells from Human Placenta. Nanomaterials (Basel) 10:N/A (2020). PubMed: 32635405
- Fraichard C et al. Placental production of progestins is fully effective in villous cytotrophoblasts and increases with the syncytiotrophoblast formation. Mol Cell Endocrinol 499:110586 (2020). PubMed: 31539598