WIKI4,Wnt/ beta catenin抑制剂(ab147053)
Key features and details
- Potent Wnt/ beta catenin inhibitor
- CAS Number: 838818-26-1
- Purity: > 98%
- Soluble in DMSO to 20 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
WIKI4,Wnt/ beta catenin抑制剂 -
描述
Potent Wnt/ beta catenin抑制剂 -
别名
- Tankyrase 1/2 Inhibitor V
- WIKI-4
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生物学描述
WIKI-4 is a potent inhibitor of Wnt/β-catenin signaling EC50 ~ 75 nM (in all cell lines tested including DLD1 colorectal cancer cells, NALM6 B cells, U-2 OS osteosarcoma cells, and hESCs); inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM). Also a potent and selective inhibitor of TNKS1 and TNKS2 (IC50s = 26 and 15 nM, respectively). It has little or no effect on related polymerases or transferases at 10 µM. Through its effects on TNKS2, WIKI4 prevents AXIN ubiquitinylation and degradation, blocking signaling through the Wnt/β-
catenin pathway. WIKI4 inhibits the expression of β- catenin target genes and cellular responses to Wnt/β- catenin signaling in both cancer cell lines and embryonic stem cells -
纯度
> 98% -
常规说明
This product is manufactured by BioVision, an Abcam company and was previously called B1630 WIKI-4. B1630-25 is the same size as the 25 mg size of ab147053.
Protect from air and light.
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CAS编号
838818-26-1
性能
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化学名称
1-[(1S)-1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]pyridin-2-one -
分子量
521.59 -
分子式
C29H23N5O3S -
PubChem识别号
2984337 -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Store In the Dark. Store under desiccating conditions. -
溶解度概述
Soluble in DMSO to 20 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=CC=C(C=C1)N2C(=NN=C2SCCCN3C(=O)C4=CC=CC5=C4C(=CC=C5)C3=O)C6=CC=NC=C6 -
来源
Synthetic
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab147053 尚未被引用在任何文献中。