Alsterpaullone,cyclin-dependent kinase (CDK) and GSK-3beta抑制剂(ab141070)
Key features and details
- Potent cyclin-dependent kinase (CDK) and GSK-3β inhibitor
- CAS Number: 237430-03-4
- Purity: > 96%
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Alsterpaullone,cyclin-dependent kinase (CDK) and GSK-3beta抑制剂 -
描述
Potent cyclin-dependent kinase (CDK) and GSK-3β抑制剂 -
纯度
> 96% -
CAS编号
237430-03-4 -
化学结构
性能
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化学名称
7,12-Dihydro-9-nitroindolo[3,2-d][1]benzazepin-6(5H)-one -
分子量
293.28 -
分子式
C16H11N3O3 -
PubChem识别号
5005498 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
[O-][N+](=O)c4cc3c(NC1C3CC(=O)Nc2ccccc12)cc4 -
来源
Synthetic
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研究领域
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Integration of energy
- Biochemicals
- Research Area
- Alzheimer's Disease
- Apoptosis & cell cycle
- Cyclin-dependent kinase
- Inhibitors
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Apoptosis & cell cycle
- Cyclin-dependent kinase
- Inhibitors
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Apoptosis & cell cycle
- Cyclin-dependent kinase
- Inhibitors
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Apoptosis & cell cycle
- Cyclin-dependent kinase
- Inhibitors
- Biochemicals
- Research Area
- Obesity
- Signaling
- Apoptosis & cell cycle
- Cyclin-dependent kinase
- Inhibitors
- Biochemicals
- Research Area
- Pain & inflammation
- Apoptosis & cell cycle
- Cyclin-dependent kinase
- Inhibitors
图片
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2D chemical structure image of ab141070, Alsterpaullone, cyclin-dependent kinase (CDK) and GSK-3beta inhibitor
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ab32505 staining AKT1 in SK-N-SH cells treated with alsterpaullone (ab141070), by ICC/IF. Decrease of AKT1 expression correlates with increased concentration of alsterpaullone, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab141070 (alsterpaullone) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab32505 (1/200 dilution was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab141070 尚未被引用在任何文献中。