Memantine hydrochloride,NMDA拮抗剂(ab120249)
Key features and details
- NMDA antagonist, ion channel site
- CAS Number: 41100-52-1
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
-
产品名称
Memantine hydrochloride,NMDA拮抗剂 -
描述
NMDA拮抗剂,ion channel site -
生物学描述
Antagonist at the NMDA receptor. Acts as a fast, voltage-dependent, open channel NMDA receptor blocker. Used in the clinic to treat Alzheimer's disease. Cognitive enhancer and anxiolytic in vivo.
Also available in simple stock solutions (ab146687) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS编号
41100-52-1 -
化学结构
性能
-
化学名称
3,5-Dimethyl-1-adamantanamine hydrochloride -
分子量
215.77 -
分子式
C12H21N.HCl -
PubChem识别号
181458 -
存放说明
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
Cl.CC13CC2(C)CC(N)(C1)CC(C2)C3 -
来源
Synthetic
-
研究领域
图片
-
2D chemical structure image of ab120249, Memantine hydrochloride, NMDA antagonist
-
Averaged time courses of NMDA receptor-isolated synaptic field potentials in dorsal lateral bed nucleus of the stria terminalis following 60 minutes of memantine (5 or 30 μM; ab120249) in naive adult male C57BL/6J mice.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (1)
ab120249 被引用在 1 文献中.
- Wills TA et al. GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis. Proc Natl Acad Sci U S A 109:E278-87 (2012). PubMed: 22219357