Anti-A1CF抗体(ab89050)

概述

  • 产品名称Anti-A1CF抗体
    参阅全部 A1CF 一抗
  • 描述
    小鼠多克隆抗体to A1CF
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length protein, corresponding to amino acids 1-594 of Human A1CF (NP_620311.1)

  • 阳性对照
    • Placenta or HeLa cell lysate.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab89050 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 65 kDa.

靶标

  • 功能Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.
  • 组织特异性Widely expressed with highest levels in brain, liver, pancreas, colon and spleen.
  • 序列相似性Contains 3 RRM (RNA recognition motif) domains.
  • 结构域The RRM domains are necessary but not sufficient for binding to APOB mRNA. Additional residues in the pre-RRM and C-terminal regions are required for RNA-binding and for complementing APOBEC1 activity.
  • 细胞定位Nucleus. Endoplasmic reticulum. Cytoplasm. Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1.
  • Information by UniProt
  • 数据库链接
  • 别名
    • A1CF antibody
    • A1CF_HUMAN antibody
    • ACF antibody
    • ACF64 antibody
    • ACF65 antibody
    • Apo B RNA editing protein antibody
    • Apobec 1 complementation factor antibody
    • Apobec 1 complementation factor (ACF) (ASP) antibody
    • APOBEC 1 stimulating protein antibody
    • APOBEC1 complementation factor antibody
    • APOBEC1 stimulating protein antibody
    • APOBEC1-stimulating protein antibody
    • APOBEC1CF antibody
    • ASP antibody
    • MGC163391 antibody
    • RP11-564C4.2 antibody
    see all

Anti-A1CF antibody 图像

  • Anti-A1CF antibody (ab89050) at 1 µg/ml + Human placenta lysate at 50 µg

    Predicted band size : 65 kDa
  • Anti-A1CF antibody (ab89050) at 1 µg/ml + HeLa cell lysate at 50 µg

    Predicted band size : 65 kDa
  • All lanes : Anti-A1CF antibody (ab89050) at 1 µg/ml

    Lane 1 : A1CF-transfected 293T cell lysate
    Lane 2 : non transfected lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 65 kDa
    Observed band size : 65 kDa

Anti-A1CF antibody (ab89050)参考文献

ab89050 has not yet been referenced specifically in any publications.

Product Wall

I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement for one vial of ab89050. To check the status of the order please contact our Customer...

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