概述

  • 产品名称
    A 438079
  • 描述
    Potent, competitive P2X7 receptor antagonist
  • 生物学描述
    Potent, competitive P2X7 receptor antagonist (pIC50 = 6.5 nM). Shown to reduce pathological nociception.
  • 纯度
    > 98%

性能

  • 化学名称
    3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine hydrochloride
  • 分子量
    342.61
  • 化学结构
    Chemical Structure
  • 分子式
    C13H9Cl2N5.HCl
  • CAS编号
    899507-36-9
  • PubChem识别号
    11688742
  • 存放说明
    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解度概述
    Soluble in DMSO to 100 mM and in water to 5 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    Cl.Clc3cccc(c2nnnn2Cc1cnccc1)c3Cl
  • 来源

    Synthetic

  • 研究领域

文献

This product has been referenced in:
  • Marcellino D  et al. On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X(7) receptor antagonist A-438079. J Neural Transm 117:681-7 (2010). Read more (PubMed: 20387084) »
  • Donnelly-Roberts DL & Jarvis MF Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states. Br J Pharmacol 151:571-9 (2007). Read more (PubMed: 17471177) »
  • McGaraughty S  et al. P2X7-related modulation of pathological nociception in rats. Neuroscience 146:1817-28 (2007). Read more (PubMed: 17478048) »

See 0 Publications for this product

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