概述

  • 产品名称A 438079
  • 描述
    Potent, competitive P2X7 receptor antagonist
  • 生物学描述Potent, competitive P2X7 receptor antagonist (pIC50 = 6.5 nM). Shown to reduce pathological nociception.
  • 纯度> 98%

性能

  • 化学名称3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine hydrochloride
  • 分子量342.61
  • 化学结构Chemical Structure
  • 分子式C13H9Cl2N5.HCl
  • CAS编号899507-36-9
  • PubChem识别号11688742
  • 存放说明Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解度概述Soluble in DMSO to 100 mM and in water to 5 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESCl.Clc3cccc(c2nnnn2Cc1cnccc1)c3Cl
  • 来源

    Synthetic

  • 研究领域

    A 438079 (ab120413)参考文献

    This product has been referenced in:
    • Marcellino D  et al. On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X(7) receptor antagonist A-438079. J Neural Transm 117:681-7 (2010). Read more (PubMed: 20387084) »
    • Donnelly-Roberts DL & Jarvis MF Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states. Br J Pharmacol 151:571-9 (2007). Read more (PubMed: 17471177) »
    • McGaraughty S  et al. P2X7-related modulation of pathological nociception in rats. Neuroscience 146:1817-28 (2007). Read more (PubMed: 17478048) »

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