Anti-XRCC1 (phospho S518 + T519 + T523)抗体(ab84417)
Key features and details
- Rabbit polyclonal to XRCC1 (phospho S518 + T519 + T523)
- Suitable for: IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-XRCC1 (phospho S518 + T519 + T523)抗体
参阅全部 XRCC1 一抗 -
描述
兔多克隆抗体to XRCC1 (phospho S518 + T519 + T523) -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Mouse, Human
预测可用于: Chimpanzee, Gorilla -
免疫原
Synthetic peptide corresponding to Human XRCC1 (phospho S518 + T519 + T523).
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阳性对照
- IHC: Human breast carcinoma, Mouse squamous cell carcinoma.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 6.8
Preservative: 0.09% Sodium azide
Constituents: 0.1% BSA, Tris buffered saline -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab84417于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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说明 |
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IHC-P
1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. -
序列相似性
Contains 2 BRCT domains. -
翻译后修饰
Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.
Sumoylated. -
细胞定位
Nucleus. Accumulates at sites of DNA damage. - Information by UniProt
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数据库链接
- Entrez Gene: 7515 Human
- Entrez Gene: 22594 Mouse
- Omim: 194360 Human
- SwissProt: P18887 Human
- SwissProt: Q60596 Mouse
- Unigene: 98493 Human
- Unigene: 4347 Mouse
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别名
- DNA repair protein XRCC1 antibody
- RCC antibody
- X ray repair complementing defective repair in chinese hamster antibody
see all
图片
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Detection of Human XRCC1 (phospho S518 + T519 + T523) by Immunohistochemistry.
Samples: FFPE serial sections of Human breast adenocarcinoma. Mock phosphatase treated section (left) or calf intestinal phosphatase-treated section (right) immunostained for XRCC1 (phospho S518 + T519 + T523).Antibody: ab84417 used at a dilution of 1/250.
Detection: DAB staining. -
Detection of Mouse XRCC1 (phospho S518 + T519 + T523) by Immunohistochemistry.
Samples: FFPE serial sections of Mouse squamous cell carcinoma. Mock phosphatase treated section (left) or calf intestinal phosphatase-treated section (right) immunostained for XRCC1 (phospho S518 + T519 + T523).Antibody: ab84417 used at a dilution of 1/250. Detection: DAB staining. -
Detection of Human XRCC1 (phospho S518 + T519 + T523) by Immunofluorescence.
Sample: FFPE section of Human breast carcinoma.Antibody: ab84417 used at a dilution of 1/100.
Detection: Red-fluorescent Alexa Fluor 555 goat anti-rabbit IgG used at a dilution of 1/500.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab84417 被引用在 1 文献中.
- Lord T & Aitken RJ Fertilization stimulates 8-hydroxy-2'-deoxyguanosine repair and antioxidant activity to prevent mutagenesis in the embryo. Dev Biol 406:1-13 (2015). PubMed: 26234752