Anti-VEGFC抗体[9/E7] (ab106512)
Key features and details
- Mouse monoclonal [9/E7] to VEGFC
- Suitable for: IHC-P, IHC-Fr
- Reacts with: Rat, Human
- Isotype: IgG2a
概述
-
产品名称
Anti-VEGFC抗体[9/E7]
参阅全部 VEGFC 一抗 -
描述
小鼠单克隆抗体[9/E7] to VEGFC -
宿主
Mouse -
经测试应用
适用于: IHC-P, IHC-Frmore details -
种属反应性
与反应: Rat, Human -
免疫原
Recombinant fragment (His-tag) corresponding to Human VEGFC aa 103-215.
Database link: P49767 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Lyophilized:Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Constituent: PBS -
Concentration information loading...
-
纯度
Protein G purified -
克隆
单克隆 -
克隆编号
9/E7 -
同种型
IgG2a -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab106512于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P |
Use a concentration of 2 - 10 µg/ml.
|
|
IHC-Fr |
Use a concentration of 2 - 10 µg/ml.
|
说明 |
---|
IHC-P
Use a concentration of 2 - 10 µg/ml. |
IHC-Fr
Use a concentration of 2 - 10 µg/ml. |
靶标
-
功能
Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. -
组织特异性
Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte. -
序列相似性
Belongs to the PDGF/VEGF growth factor family. -
翻译后修饰
Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing an heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions. -
细胞定位
Secreted. - Information by UniProt
-
数据库链接
- Entrez Gene: 7424 Human
- Entrez Gene: 114111 Rat
- Omim: 601528 Human
- SwissProt: P49767 Human
- SwissProt: Q6FH59 Human
- SwissProt: O35757 Rat
- Unigene: 435215 Human
- Unigene: 6913 Rat
-
别名
- Flt 4L antibody
- Flt4 ligand antibody
- FLT4 ligand DHM antibody
see all
图片
-
Immunohistochemistry (Frozen sections) analysis of rat mammary tumor tissue sections labelling VEGFC with ab106512.
-
Immunohistochemistry (Frozen sections) analysis of rat mammary tumor tissue sections labelling VEGFC with ab106512.
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human colon carcinoma tissue sections labelling VEGFC with ab106512.
数据表及文件
-
Datasheet download
文献 (3)
ab106512 被引用在 3 文献中.
- Kusumoto S et al. An immature inhibin-a-expressing subpopulation of ovarian clear cell carcinoma cells is related to an unfavorable prognosis. Cancer Med 10:1485-1500 (2021). PubMed: 33611864
- Liu X et al. Subdural haematomas drain into the extracranial lymphatic system through the meningeal lymphatic vessels. Acta Neuropathol Commun 8:16 (2020). PubMed: 32059751
- Loessner D et al. A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns. Biomaterials 190-191:63-75 (2019). PubMed: 30396040