Anti-USP19抗体(ab93159)
Key features and details
- Rabbit polyclonal to USP19
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-USP19抗体
参阅全部 USP19 一抗 -
描述
兔多克隆抗体to USP19 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Mouse, Human
预测可用于: Rat -
免疫原
Synthetic peptide derived from an internal region of Human USP19
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab93159于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/1000. Predicted molecular weight: 145 kDa.
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IHC-P |
1/50 - 1/100.
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说明 |
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WB
1/500 - 1/1000. Predicted molecular weight: 145 kDa. |
IHC-P
1/50 - 1/100. |
靶标
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功能
Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. -
序列相似性
Belongs to the peptidase C19 family.
Contains 2 CS domains.
Contains 1 MYND-type zinc finger. -
翻译后修饰
Phosphorylated upon DNA damage, probably by ATM or ATR. -
细胞定位
Endoplasmic reticulum membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 10869 Human
- Entrez Gene: 71472 Mouse
- Entrez Gene: 361190 Rat
- Omim: 614471 Human
- SwissProt: O94966 Human
- SwissProt: Q3UJD6 Mouse
- SwissProt: Q6J1Y9 Rat
- Unigene: 255596 Human
see all -
别名
- 8430421I07Rik antibody
- AI047774 antibody
- Deubiquitinating enzyme 19 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (6)
ab93159 被引用在 6 文献中.
- Zhao X et al. USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy. Autophagy 18:891-908 (2022). PubMed: 34436957
- Hu W et al. Ubiquitin specific peptidase 19 is a prognostic biomarker and affect the proliferation and migration of clear cell renal cell carcinoma. Oncol Rep 43:1964-1974 (2020). PubMed: 32236633
- Gierisch ME et al. USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth. Sci Rep 9:951 (2019). PubMed: 30700749
- Wu X et al. Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination. Nat Commun 10:4115 (2019). PubMed: 31511519
- Lei CQ et al. USP19 Inhibits TNF-a- and IL-1ß-Triggered NF-?B Activation by Deubiquitinating TAK1. J Immunol 203:259-268 (2019). PubMed: 31127032
- Ogawa M et al. 17ß-estradiol represses myogenic differentiation by increasing ubiquitin-specific peptidase 19 through estrogen receptor a. J Biol Chem 286:41455-65 (2011). WB ; Mouse . PubMed: 21971047