Anti-UNC13B抗体(ab97924)
Key features and details
- Rabbit polyclonal to UNC13B
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-UNC13B抗体
参阅全部 UNC13B 一抗 -
描述
兔多克隆抗体to UNC13B -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Zebrafish -
免疫原
Recombinant protein fragment corresponding to a region within amino acids 680 and 927 of Human UNC13B (NP_006368)
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阳性对照
- 293T, H1299, HeLa or HepG2 cell lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab97924于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 181 kDa.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 181 kDa. |
靶标
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功能
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. -
组织特异性
Expressed in kidney cortical epithelial cells and brain. -
序列相似性
Belongs to the unc-13 family.
Contains 3 C2 domains.
Contains 1 MHD1 (MUNC13 homology domain 1) domain.
Contains 1 MHD2 (MUNC13 homology domain 2) domain.
Contains 1 phorbol-ester/DAG-type zinc finger. -
结构域
The C2 domains are not involved in calcium-dependent phospholipid binding. -
细胞定位
Cytoplasm. Membrane. Cell membrane. Cell junction > synapse. Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding. - Information by UniProt
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数据库链接
- Entrez Gene: 10497 Human
- Entrez Gene: 22249 Mouse
- Entrez Gene: 64830 Rat
- Omim: 605836 Human
- SwissProt: O14795 Human
- SwissProt: Q9Z1N9 Mouse
- SwissProt: Q62769 Rat
- Unigene: 493791 Human
see all -
别名
- hmunc13 antibody
- MGC133279 antibody
- MGC133280 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab97924 被引用在 3 文献中.
- Brown AL et al. TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A. Nature 603:131-137 (2022). PubMed: 35197628
- Oguchi ME et al. A comprehensive analysis of Rab GTPases reveals a role for Rab34 in serum starvation-induced primary ciliogenesis. J Biol Chem 295:12674-12685 (2020). PubMed: 32669361
- Xu R et al. Munc13-4 mediates human neutrophil elastase-induced airway mucin5AC hypersecretion by interacting with syntaxin2. Mol Med Rep 18:1015-1024 (2018). PubMed: 29767240