Anti-ULBP3抗体[MM0594-6E12] (ab89931)
Key features and details
- Mouse monoclonal [MM0594-6E12] to ULBP3
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG2
概述
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产品名称
Anti-ULBP3抗体[MM0594-6E12]
参阅全部 ULBP3 一抗 -
描述
小鼠单克隆抗体[MM0594-6E12] to ULBP3 -
宿主
Mouse -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length Human ULBP3 protein
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Constituent: PBS -
Concentration information loading...
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纯度
Protein G purified -
纯化说明
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and filtered through a 0.2 µm filter. -
克隆
单克隆 -
克隆编号
MM0594-6E12 -
同种型
IgG2 -
研究领域
相关产品
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Compatible Secondaries
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab89931于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
Use at an assay dependent concentration.
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说明 |
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IHC-P
Use at an assay dependent concentration. |
靶标
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功能
Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for KLRK1/NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1. -
序列相似性
Belongs to the MHC class I family. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 79465 Human
- Omim: 605699 Human
- SwissProt: Q9BZM4 Human
- Unigene: 15422 Human
- Unigene: 326556 Human
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别名
- ALCAN- gamma antibody
- ALCAN-gamma antibody
- N2DL-3 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human placental tissue section (4µm) labelling ULBP3 with ab89931. Tissue was treated with 15µg/ml Protenase for antigen retrieval and fixed with 4% PFA. A HRP-conjugated anti-mouse IgG was used as the secondary antibody (30 minutes at room temperature) followed by DAB color development.
数据表及文件
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Datasheet download
文献 (2)
ab89931 被引用在 2 文献中.
- Ma Y et al. circRNA of AR-suppressed PABPC1 91 bp enhances the cytotoxicity of natural killer cells against hepatocellular carcinoma via upregulating UL16 binding protein 1. Oncol Lett 17:388-397 (2019). PubMed: 30655779
- Cho H et al. MICA/B and ULBP1 NKG2D ligands are independent predictors of good prognosis in cervical cancer. BMC Cancer 14:957 (2014). IHC-P ; Human . PubMed: 25510288