Anti-UL42抗体[2H4] (ab19311)
Key features and details
- Mouse monoclonal [2H4] to UL42
- Suitable for: IP, ELISA, IHC-Fr, WB, ICC/IF
- Reacts with: Herpes simplex virus
- Isotype: IgG1
概述
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产品名称
Anti-UL42抗体[2H4]
参阅全部 UL42 一抗 -
描述
小鼠单克隆抗体[2H4] to UL42 -
宿主
Mouse -
特异性
2H4 will recognise UL42 bound to HSV polymerase. -
经测试应用
适用于: IP, ELISA, IHC-Fr, WB, ICC/IFmore details -
种属反应性
与反应: Herpes simplex virus -
免疫原
Baculovirus-expressed HSV DNA polymerase (POL) and POL/UL42 complex.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.02% Sodium azide
Constituent: 99.98% PBS -
Concentration information loading...
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纯度
Protein A/G purified -
克隆
单克隆 -
克隆编号
2H4 -
骨髓瘤
Sp2/0 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab19311于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IP | ||
ELISA | ||
IHC-Fr | ||
WB | ||
ICC/IF |
说明 |
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ICC/IF: Use at an assay dependent dilution PMID 17553899.
IHC-Fr: Use at an assay dependent dilution.
IP: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 13.6 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
靶标
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相关性
UL42 is the DNA polymerase accessory protein of herpes simplex virus type 1. -
细胞定位
Nuclear -
数据库链接
- Entrez Gene: 2703407 Herpes simplex virus
- SwissProt: P10226 Herpes simplex virus
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别名
- HHV1gp061 antibody
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (6)
ab19311 被引用在 6 文献中.
- Qin S et al. Hsp90 Inhibitors Prevent HSV-1 Replication by Directly Targeting UL42-Hsp90 Complex. Front Microbiol 12:797279 (2021). PubMed: 35185822
- Harancher MR et al. Antiviral Properties of the LSD1 Inhibitor SP-2509. J Virol 94:N/A (2020). PubMed: 32699090
- Döhner K et al. Importin a1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons. PLoS Pathog 14:e1006823 (2018). PubMed: 29304174
- Lv C et al. Ivermectin inhibits DNA polymerase UL42 of pseudorabies virus entrance into the nucleus and proliferation of the virus in vitro and vivo. Antiviral Res 159:55-62 (2018). PubMed: 30266338
- Dembowski JA et al. Replication-Coupled Recruitment of Viral and Cellular Factors to Herpes Simplex Virus Type 1 Replication Forks for the Maintenance and Expression of Viral Genomes. PLoS Pathog 13:e1006166 (2017). PubMed: 28095497
- Chen Y et al. A mutation in the human herpes simplex virus type 1 UL52 zinc finger motif results in defective primase activity but can recruit viral polymerase and support viral replication efficiently. J Virol 81:8742-51 (2007). WB, ICC/IF . PubMed: 17553899